Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study

Dong Wei Li; Zu De Qi; Xin Liang Ding; Jia Han Li; Feng Lei Jiang; Yi Liu; Daniel W J KWONG; Rick W K WONG

doi:10.1016/j.jlumin.2012.06.041

Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study

Dong Wei Li, Zu De Qi, Xin Liang Ding, Jia Han Li, Feng Lei Jiang, Yi Liu^*, Daniel W J KWONG, Rick W K WONG

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

2 Citations (Scopus)

Abstract

In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs.

Original language	English
Pages (from-to)	830-836
Number of pages	7
Journal	Journal of Luminescence
Volume	134
DOIs	https://doi.org/10.1016/j.jlumin.2012.06.041
Publication status	Published - Feb 2013

Scopus Subject Areas

Biophysics
Biochemistry
Chemistry(all)
Atomic and Molecular Physics, and Optics
Condensed Matter Physics

User-Defined Keywords

AOT reverse micelles
Delocalized lipophilic cations
Fluorescence method
Mitochondria

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10.1016/j.jlumin.2012.06.041

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title = "Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study",

abstract = "In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs.",

keywords = "AOT reverse micelles, Delocalized lipophilic cations, Fluorescence method, Mitochondria",

author = "Li, {Dong Wei} and Qi, {Zu De} and Ding, {Xin Liang} and Li, {Jia Han} and Jiang, {Feng Lei} and Yi Liu and KWONG, {Daniel W J} and WONG, {Rick W K}",

year = "2013",

month = feb,

doi = "10.1016/j.jlumin.2012.06.041",

language = "English",

volume = "134",

pages = "830--836",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier",

}

TY - JOUR

T1 - Photophysics of three delocalized lipophilic cations in reverse micelles

T2 - A fluorescence spectroscopy study

AU - Li, Dong Wei

AU - Qi, Zu De

AU - Ding, Xin Liang

AU - Li, Jia Han

AU - Jiang, Feng Lei

AU - Liu, Yi

AU - KWONG, Daniel W J

AU - WONG, Rick W K

PY - 2013/2

Y1 - 2013/2

N2 - In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs.

AB - In this paper, aiming at the trans-membrane transport properties of the different DLCs related with the cytotoxicities, we have studied photophysics of DLCs in RMs. MTT assays indicated that DLC 1 were more cytotoxic than DLC 2 and 3. Steady-state absorption and fluorescence method have been used to characterize the binding model of three DLCs (1, 2, and 3) in RMs and bovine serum albumin (BSA). The progressive red-shift of compound 1 indicated that it can experience the hydrophilic and hydrophobic environment owing to the rigid structure, thus it can more easily cross the double membrane of cell than compounds 2 and 3. In conclusion, we simulated a model of compound 1 in RMs. The present study of F16 derivatives in microenvironment would provide some useful information to the cell membrane simulation and design of DLCs.

KW - AOT reverse micelles

KW - Delocalized lipophilic cations

KW - Fluorescence method

KW - Mitochondria

UR - http://www.scopus.com/inward/record.url?scp=84869490874&partnerID=8YFLogxK

U2 - 10.1016/j.jlumin.2012.06.041

DO - 10.1016/j.jlumin.2012.06.041

M3 - Journal article

AN - SCOPUS:84869490874

SN - 0022-2313

VL - 134

SP - 830

EP - 836

JO - Journal of Luminescence

JF - Journal of Luminescence

ER -

Photophysics of three delocalized lipophilic cations in reverse micelles: A fluorescence spectroscopy study

Abstract

Scopus Subject Areas

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