Photocytotoxicity and magnetic relaxivity responses of dual-porous γ-Fe 2O 3@ meso -SiO 2 microspheres

Shou Hu Xuan; Siu Fung Lee; Janet Ting Fong Lau; Xiaoming Zhu; Yi Xiang J. Wang; Feng Wang; Josie M.Y. Lai; Kathy W.Y. Sham; Pui Chi Lo; Jimmy C. Yu; Christopher H.K. Cheng; Ken C F LEUNG

doi:10.1021/am300008x

Photocytotoxicity and magnetic relaxivity responses of dual-porous γ-Fe ₂O ₃@ meso -SiO ₂ microspheres

Shou Hu Xuan, Siu Fung Lee, Janet Ting Fong Lau, Xiaoming Zhu, Yi Xiang J. Wang, Feng Wang, Josie M.Y. Lai, Kathy W.Y. Sham, Pui Chi Lo, Jimmy C. Yu, Christopher H.K. Cheng, Ken C F LEUNG^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

46 Citations (Scopus)

Abstract

Novel high magnetization microspheres with porous γ-Fe ₂O ₃ core and porous SiO ₂ shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared γ-Fe ₂O ₃@meso-SiO ₂ microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the γ-Fe ₂O ₃ porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r ₂ (76.5 s ^-1 mM ^-1 Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m ²/g), demonstrating that they can be used as a bifunctional agent for both MRI and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form γ-Fe ₂O ₃@meso-SiO ₂-ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (λ > 610 nm) of the HT29 cells uptaken with γ-Fe ₂O ₃@meso-SiO ₂-ZnPC microspheres has been demonstrated for 20 min illumination.

Original language	English
Pages (from-to)	2033-2040
Number of pages	8
Journal	ACS Applied Materials and Interfaces
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/am300008x
Publication status	Published - 25 Apr 2012

Scopus Subject Areas

General Materials Science

User-Defined Keywords

drug carrier
magnetic resonance imaging
nanoparticle
photocytotoxicity
porosity

Access to Document

10.1021/am300008x

Cite this

@article{f7b05e162bba4c958d31d6455d761d77,

title = "Photocytotoxicity and magnetic relaxivity responses of dual-porous γ-Fe 2O 3@ meso -SiO 2 microspheres",

abstract = "Novel high magnetization microspheres with porous γ-Fe 2O 3 core and porous SiO 2 shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared γ-Fe 2O 3@meso-SiO 2 microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the γ-Fe 2O 3 porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r 2 (76.5 s -1 mM -1 Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m 2/g), demonstrating that they can be used as a bifunctional agent for both MRI and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form γ-Fe 2O 3@meso-SiO 2-ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (λ > 610 nm) of the HT29 cells uptaken with γ-Fe 2O 3@meso-SiO 2-ZnPC microspheres has been demonstrated for 20 min illumination.",

keywords = "drug carrier, magnetic resonance imaging, nanoparticle, photocytotoxicity, porosity",

author = "Xuan, {Shou Hu} and Lee, {Siu Fung} and Lau, {Janet Ting Fong} and Xiaoming Zhu and Wang, {Yi Xiang J.} and Feng Wang and Lai, {Josie M.Y.} and Sham, {Kathy W.Y.} and Lo, {Pui Chi} and Yu, {Jimmy C.} and Cheng, {Christopher H.K.} and LEUNG, {Ken C F}",

note = "We acknowledge the financial support by RGC-GRF (401709), UGC (AoE/P-03/08) research grants and NSFC (11102202). ",

year = "2012",

month = apr,

day = "25",

doi = "10.1021/am300008x",

language = "English",

volume = "4",

pages = "2033--2040",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Photocytotoxicity and magnetic relaxivity responses of dual-porous γ-Fe 2O 3@ meso -SiO 2 microspheres

AU - Xuan, Shou Hu

AU - Lee, Siu Fung

AU - Lau, Janet Ting Fong

AU - Zhu, Xiaoming

AU - Wang, Yi Xiang J.

AU - Wang, Feng

AU - Lai, Josie M.Y.

AU - Sham, Kathy W.Y.

AU - Lo, Pui Chi

AU - Yu, Jimmy C.

AU - Cheng, Christopher H.K.

AU - LEUNG, Ken C F

N1 - We acknowledge the financial support by RGC-GRF (401709), UGC (AoE/P-03/08) research grants and NSFC (11102202).

PY - 2012/4/25

Y1 - 2012/4/25

N2 - Novel high magnetization microspheres with porous γ-Fe 2O 3 core and porous SiO 2 shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared γ-Fe 2O 3@meso-SiO 2 microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the γ-Fe 2O 3 porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r 2 (76.5 s -1 mM -1 Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m 2/g), demonstrating that they can be used as a bifunctional agent for both MRI and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form γ-Fe 2O 3@meso-SiO 2-ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (λ > 610 nm) of the HT29 cells uptaken with γ-Fe 2O 3@meso-SiO 2-ZnPC microspheres has been demonstrated for 20 min illumination.

AB - Novel high magnetization microspheres with porous γ-Fe 2O 3 core and porous SiO 2 shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared γ-Fe 2O 3@meso-SiO 2 microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the γ-Fe 2O 3 porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r 2 (76.5 s -1 mM -1 Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m 2/g), demonstrating that they can be used as a bifunctional agent for both MRI and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form γ-Fe 2O 3@meso-SiO 2-ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (λ > 610 nm) of the HT29 cells uptaken with γ-Fe 2O 3@meso-SiO 2-ZnPC microspheres has been demonstrated for 20 min illumination.

KW - drug carrier

KW - magnetic resonance imaging

KW - nanoparticle

KW - photocytotoxicity

KW - porosity

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U2 - 10.1021/am300008x

DO - 10.1021/am300008x

M3 - Journal article

C2 - 22409402

AN - SCOPUS:84860329349

SN - 1944-8244

VL - 4

SP - 2033

EP - 2040

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 4

ER -