Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex

Edmond Dik Lung MA; Hai Jing Zhong; Wai Chung Fu; Daniel Shiu Hin Chan; Hiu Yee Kwan; David Wang Fun Fong; Lai Hon Chung; Chun Yuen Wong; Chung Hang Leung

doi:10.1371/journal.pone.0055751

Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex

Edmond Dik Lung MA^*
, Hai Jing Zhong
, Wai Chung Fu
, Daniel Shiu Hin Chan
, Hiu Yee Kwan
, David Wang Fun Fong
, Lai Hon Chung
, Chun Yuen Wong
, Chung Hang Leung

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

39 Citations (Scopus)

Abstract

A cell permeable cyclometalated iridium(III) complex has been developed as a phosphorescent probe for cell imaging. The iridium(III) solvato complex [Ir(phq)₂(H₂O]₂)] preferentially stains the cytoplasm of both live and dead cells with a bright luminescence.

Original language	English
Article number	e55751
Number of pages	8
Journal	PLoS ONE
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0055751
Publication status	Published - 14 Feb 2013

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title = "Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex",

abstract = "A cell permeable cyclometalated iridium(III) complex has been developed as a phosphorescent probe for cell imaging. The iridium(III) solvato complex [Ir(phq)2(H2O]2)] preferentially stains the cytoplasm of both live and dead cells with a bright luminescence.",

author = "MA, \{Edmond Dik Lung\} and Zhong, \{Hai Jing\} and Fu, \{Wai Chung\} and Chan, \{Daniel Shiu Hin\} and Kwan, \{Hiu Yee\} and Fong, \{David Wang Fun\} and Chung, \{Lai Hon\} and Wong, \{Chun Yuen\} and Leung, \{Chung Hang\}",

note = "This work is supported by Hong Kong Baptist University (FRG2/11–12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811) and the University of Macau (SRG013-ICMS12-LCH, MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L2)-ICMS12-LCH). ",

year = "2013",

month = feb,

day = "14",

doi = "10.1371/journal.pone.0055751",

language = "English",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

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T1 - Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex

AU - MA, Edmond Dik Lung

AU - Zhong, Hai Jing

AU - Fu, Wai Chung

AU - Chan, Daniel Shiu Hin

AU - Kwan, Hiu Yee

AU - Fong, David Wang Fun

AU - Chung, Lai Hon

AU - Wong, Chun Yuen

AU - Leung, Chung Hang

N1 - This work is supported by Hong Kong Baptist University (FRG2/11–12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811) and the University of Macau (SRG013-ICMS12-LCH, MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L2)-ICMS12-LCH).

PY - 2013/2/14

Y1 - 2013/2/14

N2 - A cell permeable cyclometalated iridium(III) complex has been developed as a phosphorescent probe for cell imaging. The iridium(III) solvato complex [Ir(phq)2(H2O]2)] preferentially stains the cytoplasm of both live and dead cells with a bright luminescence.

AB - A cell permeable cyclometalated iridium(III) complex has been developed as a phosphorescent probe for cell imaging. The iridium(III) solvato complex [Ir(phq)2(H2O]2)] preferentially stains the cytoplasm of both live and dead cells with a bright luminescence.

UR - https://www.scopus.com/pages/publications/84874008820

U2 - 10.1371/journal.pone.0055751

DO - 10.1371/journal.pone.0055751

M3 - Journal article

C2 - 23457478

AN - SCOPUS:84874008820

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 2

M1 - e55751

ER -

Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex

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