Phenylpropanoid and flavonoids from osteoprotective fraction of Drynaria fortunei

A new phenylpropanoid (1), 12-O-caffeoyl-12-hydroxyldodecanoic acid, and a new chalcone (2), 3′-lavandulyl-4-methoxyl-2,2′,4′,6′- tetrahydroxylchalcone, together with eight known compounds including one chalcone (3), five flavanones (4-8) and two flavonols (9, 10), have been isolated from one of the osteoprotective fractions of Drynaria fortunei (Kunze) J. Sm., which is used as a folk medicine for the treatment of osteoporosis. All these compounds were found for the first time from the genus Drynaria. The structures of the new compounds were elucidated on the basis of spectroscopic analysis.