Pharmacophore modeling for the identification of small-molecule inhibitors of TACE

Keyphrases

• Small Molecule Inhibitors 100%
• THP-1 Cells 100%
• TACE Inhibitors 100%
• Pharmacophore Modeling 100%
• Inflammation 50%
• Dose Effect 50%
• Nitric Oxide Production 50%
• Physiological Processes 50%
• Training Set 50%
• Antiproliferative Activity 50%
• Organic Compounds 50%
• Cell-free Assay 50%
• Pharmacophore Model 50%
• Soluble TNF 50%
• In-house Database 50%
• Tumor Necrosis Factor-α Converting Enzyme 50%
• Acute Monocytic Leukemia 50%
• Enzyme Inhibitors 50%
• Hematopoiesis 50%
• Enzymatic Activity 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Tumor Necrosis Factor 100%
• Tumor Necrosis Factor Alpha Converting Enzyme Inhibitor 100%
• Pharmacophore Modeling 100%
• Inflammation 50%
• Nitric Oxide 50%
• Antiproliferative Activity 50%
• Acute Monocytic Leukemia 50%
• Enzyme Inhibitor 50%
• Dipeptidyl Carboxypeptidase 50%