Abstract
The vestibular commissural synaptic transmission to the vestibular nuclei (VN) in chronic hemilabyrinthectomized (HL) frogs has been investigated in vitro.
In normal frogs commissurally evoked postsynaptic field potential in the VN are not affected by the specific N-methyl-D-aspartic acid (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV, 25 µM). However D-APV blocks a component of the commissurally evoked EPSPs in central vestibular neurons, suggesting an indirect effect of NMDA-receptors on the efficacy of these EPSPs (T. Knopfel, Neurosci.Lett. suppl.,28 (1986) S420). In HL frogs in vivo it has beenshown, that the vestibular commissure projectingto the lesioned side increase in efficacy (N. Dieringer & W. Precht, Exp. Brain Res. 36, (1979) 311-328). The present in vitro study confirm,that commissurally evoked field potentials arelarger in amplitude in HL-frogs than in normalfrogs. However, these field potentials remain D-APV insensitive. Thus, as in normal frogs, thevestibular commissural input to the VN appearsto be mediated through non-NMDA synaptic receptors.
In normal frogs commissurally evoked postsynaptic field potential in the VN are not affected by the specific N-methyl-D-aspartic acid (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV, 25 µM). However D-APV blocks a component of the commissurally evoked EPSPs in central vestibular neurons, suggesting an indirect effect of NMDA-receptors on the efficacy of these EPSPs (T. Knopfel, Neurosci.Lett. suppl.,28 (1986) S420). In HL frogs in vivo it has beenshown, that the vestibular commissure projectingto the lesioned side increase in efficacy (N. Dieringer & W. Precht, Exp. Brain Res. 36, (1979) 311-328). The present in vitro study confirm,that commissurally evoked field potentials arelarger in amplitude in HL-frogs than in normalfrogs. However, these field potentials remain D-APV insensitive. Thus, as in normal frogs, thevestibular commissural input to the VN appearsto be mediated through non-NMDA synaptic receptors.
| Original language | English |
|---|---|
| Pages (from-to) | R61 |
| Number of pages | 1 |
| Journal | Pflugers Archiv European Journal of Physiology |
| Volume | 408 |
| Issue number | 1, Supp 1 |
| DOIs | |
| Publication status | Published - Mar 1987 |
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