Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

A. M. Batchelor; T. Knöpfel; F. Gasparini; J. Garthwaite

doi:10.1016/S0028-3908(97)00014-2

Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

A. M. Batchelor^*, T. Knöpfel, F. Gasparini, J. Garthwaite

^*Corresponding author for this work

Department of Physics

Research output: Contribution to journal › Journal article › peer-review

49 Citations (Scopus)

Abstract

The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in e cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.

Original language	English
Pages (from-to)	401-403
Number of pages	3
Journal	Neuropharmacology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/S0028-3908(97)00014-2
Publication status	Published - Mar 1997

User-Defined Keywords

cerebellum
EPSP
glutamate
metabotropic glutamate receptor
mGlu1 receptor
synaptic transmission

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10.1016/S0028-3908(97)00014-2

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abstract = "The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in e cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.",

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AU - Batchelor, A. M.

AU - Knöpfel, T.

AU - Gasparini, F.

AU - Garthwaite, J.

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Y1 - 1997/3

N2 - The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in e cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.

AB - The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in e cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1.

KW - cerebellum

KW - EPSP

KW - glutamate

KW - metabotropic glutamate receptor

KW - mGlu1 receptor

KW - synaptic transmission

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U2 - 10.1016/S0028-3908(97)00014-2

DO - 10.1016/S0028-3908(97)00014-2

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AN - SCOPUS:0342981588

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ER -

Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

Abstract

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UN SDGs

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