pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

Zhiwen Cao; Wen Li; Rui Liu; Chenxi Li; Yurong Song; Guangzhi Liu; Youwen Chen; Cheng Lu; Aiping Lyu; Yuanyan Liu

doi:10.2147/IJN.S274842

pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

Zhiwen Cao, Wen Li, Rui Liu, Chenxi Li, Yurong Song, Guangzhi Liu, Youwen Chen, Cheng Lu, Aiping Lyu^*, Yuanyan Liu^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

9 Citations (Scopus)

Abstract

Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.

Original language	English
Pages (from-to)	8369-8382
Number of pages	14
Journal	International Journal of Nanomedicine
Volume	2020
Issue number	15
DOIs	https://doi.org/10.2147/IJN.S274842
Publication status	Published - 29 Oct 2020

Scopus Subject Areas

Biophysics
Bioengineering
Biomaterials
Pharmaceutical Science
Drug Discovery
Organic Chemistry

User-Defined Keywords

Auraptene
Cell imaging
Cisplatin
PH-responsive
Tumor targeting

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/IJN.S274842

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title = "pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer",

abstract = "Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.",

keywords = "Auraptene, Cell imaging, Cisplatin, PH-responsive, Tumor targeting",

author = "Zhiwen Cao and Wen Li and Rui Liu and Chenxi Li and Yurong Song and Guangzhi Liu and Youwen Chen and Cheng Lu and Aiping Lyu and Yuanyan Liu",

note = "Funding Information: This work was supported by Beijing Natural Science Foundation (7202111) and National Science and Technology Major Project (2018ZX10101001-005-003, 2018ZX10101001-005-004). All special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCM. Funding Information: This work was supported by Beijing Natural Science Foundation (72021 1 1) and National Science and T echnology Major Project (2018ZX10101001-005-003, 2018ZX10101001-005-004). All special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCM.",

year = "2020",

month = oct,

day = "29",

doi = "10.2147/IJN.S274842",

language = "English",

volume = "2020",

pages = "8369--8382",

journal = "International Journal of Nanomedicine",

issn = "1176-9114",

publisher = "Dove Medical Press Ltd.",

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}

TY - JOUR

T1 - pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

AU - Cao, Zhiwen

AU - Li, Wen

AU - Liu, Rui

AU - Li, Chenxi

AU - Song, Yurong

AU - Liu, Guangzhi

AU - Chen, Youwen

AU - Lu, Cheng

AU - Lyu, Aiping

AU - Liu, Yuanyan

N1 - Funding Information: This work was supported by Beijing Natural Science Foundation (7202111) and National Science and Technology Major Project (2018ZX10101001-005-003, 2018ZX10101001-005-004). All special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCM. Funding Information: This work was supported by Beijing Natural Science Foundation (72021 1 1) and National Science and T echnology Major Project (2018ZX10101001-005-003, 2018ZX10101001-005-004). All special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCM.

PY - 2020/10/29

Y1 - 2020/10/29

N2 - Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.

AB - Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.

KW - Auraptene

KW - Cell imaging

KW - Cisplatin

KW - PH-responsive

KW - Tumor targeting

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U2 - 10.2147/IJN.S274842

DO - 10.2147/IJN.S274842

M3 - Journal article

C2 - 33149581

AN - SCOPUS:85094671317

SN - 1176-9114

VL - 2020

SP - 8369

EP - 8382

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

IS - 15

ER -

pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

Abstract

Scopus Subject Areas

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UN SDGs

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