@article{001520da9ed0453cb7aa81687cdb8040,
title = "pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer",
abstract = "Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.",
keywords = "Auraptene, Cell imaging, Cisplatin, PH-responsive, Tumor targeting",
author = "Zhiwen Cao and Wen Li and Rui Liu and Chenxi Li and Yurong Song and Guangzhi Liu and Youwen Chen and Cheng Lu and Aiping Lyu and Yuanyan Liu",
note = "Funding Information: This work was supported by Beijing Natural Science Foundation (7202111) and National Science and Technology Major Project (2018ZX10101001-005-003, 2018ZX10101001-005-004). All special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCM. Funding Information: This work was supported by Beijing Natural Science Foundation (72021 1 1) and National Science and T echnology Major Project (2018ZX10101001-005-003, 2018ZX10101001-005-004). All special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCM.",
year = "2020",
month = oct,
day = "29",
doi = "10.2147/IJN.S274842",
language = "English",
volume = "2020",
pages = "8369--8382",
journal = "International Journal of Nanomedicine",
issn = "1176-9114",
publisher = "Dove Medical Press Ltd.",
number = "15",
}
