pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

Zhiwen Cao, Wen Li, Rui Liu, Chenxi Li, Yurong Song, Guangzhi Liu, Youwen Chen, Cheng Lu, Aiping LYU*, Yuanyan Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.
Original languageEnglish
Pages (from-to)8369-8382
Number of pages14
JournalInternational Journal of Nanomedicine
Volume2020
Issue number15
DOIs
Publication statusPublished - 29 Oct 2020

Scopus Subject Areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Auraptene
  • Cell imaging
  • Cisplatin
  • PH-responsive
  • Tumor targeting

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