pH-Dependent Cancer-Directed Photodynamic Therapy by a Water-Soluble Graphitic-Phase Carbon Nitride–Porphyrin Nanoprobe

Chi Fai Chan, Yan Zhou, Hongyu Guo, Junying Zhang*, Lijun Jiang, Wei Chen, Kwok Keung SHIU, Rick W K WONG, Ka-Leung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C3N4) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg−1 mL−1) is shown to be a new concept of photodynamic therapeutic agent (g-C3N4–P2). The pH-sensitive emission of g-C3N4 is the driving force for the generation of 1O2 from g-C3N4–P2. The amount of 1O2/light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C3N4 at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalChemPlusChem
Volume81
Issue number6
DOIs
Publication statusPublished - 1 Jun 2016

Scopus Subject Areas

  • Chemistry(all)

User-Defined Keywords

  • cancer
  • graphitic-phase carbon nitride
  • nanoparticles
  • pH-responsive materials
  • photodynamic therapy

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