Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes

Chunxue Yang; Alice Pik Shan Kong; Zongwei Cai; Arthur C.K. Chung

doi:10.1007/s11892-017-0966-0

Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes

Chunxue Yang, Alice Pik Shan Kong, Zongwei Cai^*, Arthur C.K. Chung^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

64 Citations (Scopus)

Abstract

Purpose of review: The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms.

Recent findings: Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction. POPs are synthesized chemicals and are used widely in our daily life. These chemicals are resistant to degradation in chemical or biological processes, which enable them to exist in the environment persistently and to be bio-accumulated in animal and human tissue through the food chain. Increasingly, epidemiologic studies suggest a positive association between POPs and risk of developing diabetes.

Summary: Understanding the relationship of POPs with obesity and diabetes may shed light on preventive strategies for obesity and diabetes.

Original language	English
Article number	132
Journal	Current Diabetes Reports
Volume	17
Issue number	12
DOIs	https://doi.org/10.1007/s11892-017-0966-0
Publication status	Published - Dec 2017

Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

User-Defined Keywords

diabetes
metabolic diseases
obesity
persistent organic pollutants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11892-017-0966-0

Cite this

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abstract = "Purpose of review: The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms.Recent findings: Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction. POPs are synthesized chemicals and are used widely in our daily life. These chemicals are resistant to degradation in chemical or biological processes, which enable them to exist in the environment persistently and to be bio-accumulated in animal and human tissue through the food chain. Increasingly, epidemiologic studies suggest a positive association between POPs and risk of developing diabetes.Summary: Understanding the relationship of POPs with obesity and diabetes may shed light on preventive strategies for obesity and diabetes.",

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author = "Chunxue Yang and Kong, {Alice Pik Shan} and Zongwei Cai and Chung, {Arthur C.K.}",

note = "Funding Information: This work was supported by grants from Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund, Hong Kong Baptist University; National Natural Science Foundation of China (General Program 21577115 and 21477101); the Research Grant Council of Hong Kong (RGC GRF 463612 and 14104314, 12300114); Faculty Research Grants from the Hong Kong Baptist University (FRG2/15-16/067; FRG2/16-17/049); Hong Kong Health and Medical Research Fund (HMRF/ 03144376); and HKASO research grant 2015-16. Publisher copyright: {\textcopyright} 2017, Springer Science Business Media, LLC",

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AU - Yang, Chunxue

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AU - Cai, Zongwei

AU - Chung, Arthur C.K.

N1 - Funding Information: This work was supported by grants from Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund, Hong Kong Baptist University; National Natural Science Foundation of China (General Program 21577115 and 21477101); the Research Grant Council of Hong Kong (RGC GRF 463612 and 14104314, 12300114); Faculty Research Grants from the Hong Kong Baptist University (FRG2/15-16/067; FRG2/16-17/049); Hong Kong Health and Medical Research Fund (HMRF/ 03144376); and HKASO research grant 2015-16. Publisher copyright: © 2017, Springer Science Business Media, LLC

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N2 - Purpose of review: The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms.Recent findings: Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction. POPs are synthesized chemicals and are used widely in our daily life. These chemicals are resistant to degradation in chemical or biological processes, which enable them to exist in the environment persistently and to be bio-accumulated in animal and human tissue through the food chain. Increasingly, epidemiologic studies suggest a positive association between POPs and risk of developing diabetes.Summary: Understanding the relationship of POPs with obesity and diabetes may shed light on preventive strategies for obesity and diabetes.

AB - Purpose of review: The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms.Recent findings: Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction. POPs are synthesized chemicals and are used widely in our daily life. These chemicals are resistant to degradation in chemical or biological processes, which enable them to exist in the environment persistently and to be bio-accumulated in animal and human tissue through the food chain. Increasingly, epidemiologic studies suggest a positive association between POPs and risk of developing diabetes.Summary: Understanding the relationship of POPs with obesity and diabetes may shed light on preventive strategies for obesity and diabetes.

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Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes

Abstract

Scopus Subject Areas

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