@article{79a741d835324ed8ba9d55a6f9281ac2,
title = "Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones",
abstract = "A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90\% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.",
author = "Mengxun Zhang and Tie Chen and Shisong Fang and Weihua Wu and Xin Wang and Haiqiang Wu and Yongai Xiong and Jun Song and Chenyang Li and Zhendan He and Lee, \{Chi Sing\}",
note = "Funding Information: This work was financially supported by the National Key R \& D Program of China 2017YFA0503900, the National Natural Science Foundation of China (31670360, 81973293, U1702286 and 81871631), the Shenzhen Science and Technology Innovation Committee Grant (ZDSYS201506031617582 and JCYJ20190808122213241) and the Natural Science Foundation of Guangdong Province, China (2019B1515120029 and 2017B030301016). A special acknowledgement is made to Instrumental Analysis Center of Shenzhen University for their instruments and service.",
year = "2021",
month = mar,
day = "21",
doi = "10.1039/d0ob02444a",
language = "English",
volume = "19",
pages = "2481--2486",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "11",
}
