Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones

Mengxun Zhang, Tie Chen, Shisong Fang, Weihua Wu, Xin Wang, Haiqiang Wu, Yongai Xiong, Jun Song, Chenyang Li*, Zhendan He, Chi Sing LEE

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.

Original languageEnglish
Pages (from-to)2481-2486
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number11
DOIs
Publication statusPublished - 21 Mar 2021

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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