Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones

Mengxun Zhang, Tie Chen, Shisong Fang, Weihua Wu, Xin Wang, Haiqiang Wu, Yongai Xiong, Jun Song, Chenyang Li*, Zhendan He*, Chi Sing Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

4 Citations (Scopus)


A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.

Original languageEnglish
Pages (from-to)2481-2486
Number of pages6
JournalOrganic and Biomolecular Chemistry
Issue number11
Early online date26 Feb 2021
Publication statusPublished - 21 Mar 2021

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones'. Together they form a unique fingerprint.

Cite this