Performance of atmospheric pressure gas chromatography-tandem mass spectrometry for the analysis of organochlorine pesticides in human serum

Jing Fang, Hongzhi Zhao, Yanhao Zhang, Yu He, Qianqian Sun, Shunqing Xu, Zongwei CAI*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A novel method of atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS) for the analysis of organochlorine pesticides (OCPs) in human serum was developed. Better sensitivity and selectivity were achieved compared to conventional gas chromatography-mass spectrometry (GC-MS) and GC-MS/MS. The limits of detection (LODs) of OCPs ranged from 0.22 to 0.90 pg/mL for the analysis in serum samples. The recoveries and repeatability of the developed method were evaluated from the analysis of spiked serum at three levels (0.05, 0.5, and 5 ng/mL). The recoveries ranged from 84.5 to 118.2%, and the relative standard deviations (RSDs) were less than 20%. The developed APGC-MS/MS method was applied to measure OCPs in pooled human serum from the interlaboratory comparison study. The obtained results of OCPs were within the acceptable ranges. The method has been successfully applied to the analysis of OCPs in human serum samples with the sample volume of up to 100 μL. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)4185-4191
Number of pages7
JournalAnalytical and Bioanalytical Chemistry
Volume411
Issue number18
DOIs
Publication statusPublished - 19 Jul 2019

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry

User-Defined Keywords

  • APGC
  • Human serum
  • OCPs

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