TY - JOUR
T1 - Peptide-conjugated nano delivery systems for therapy and diagnosis of cancer
AU - Gaurav, Isha
AU - Wang, Xuehan
AU - Thakur, Abhimanyu
AU - Iyaswamy, Ashok
AU - Thakur, Sudha
AU - Chen, Xiaoyu
AU - Kumar, Gaurav
AU - Li, Min
AU - Yang, Zhijun
N1 - Funding Information:
This work was funded by the Innovation and Technology Fund (ITF) of the Hong Kong Government, grant number ITS/348/18FX, and the special development funding of Hong Kong Baptist University, grant number SDF18–0319-P0.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - Peptides are strings of approximately 2–50 amino acids, which have gained huge attention for theranostic applications in cancer research due to their various advantages including better biosafety, customizability, convenient process of synthesis, targeting ability via recognizing biological receptors on cancer cells, and better ability to penetrate cell membranes. The conjugation of peptides to the various nano delivery systems (NDS) has been found to provide an added benefit toward targeted delivery for cancer therapy. Moreover, the simultaneous delivery of peptide-conjugated NDS and nano probes has shown potential for the diagnosis of the malignant progression of cancer. In this review, various barriers hindering the targeting capacity of NDS are addressed, and various approaches for conjugating peptides and NDS have been discussed. Moreover, major peptide-based functionalized NDS targeting cancer-specific receptors have been considered, including the conjugation of peptides with extracellular vesicles, which are biological nanovesicles with promising ability for therapy and the diagnosis of cancer.
AB - Peptides are strings of approximately 2–50 amino acids, which have gained huge attention for theranostic applications in cancer research due to their various advantages including better biosafety, customizability, convenient process of synthesis, targeting ability via recognizing biological receptors on cancer cells, and better ability to penetrate cell membranes. The conjugation of peptides to the various nano delivery systems (NDS) has been found to provide an added benefit toward targeted delivery for cancer therapy. Moreover, the simultaneous delivery of peptide-conjugated NDS and nano probes has shown potential for the diagnosis of the malignant progression of cancer. In this review, various barriers hindering the targeting capacity of NDS are addressed, and various approaches for conjugating peptides and NDS have been discussed. Moreover, major peptide-based functionalized NDS targeting cancer-specific receptors have been considered, including the conjugation of peptides with extracellular vesicles, which are biological nanovesicles with promising ability for therapy and the diagnosis of cancer.
KW - Cancer
KW - Extracellular vesicles
KW - Peptide
KW - Targeted nano delivery
KW - Theranostic
UR - http://www.scopus.com/inward/record.url?scp=85115792788&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics13091433
DO - 10.3390/pharmaceutics13091433
M3 - Review article
AN - SCOPUS:85115792788
SN - 1999-4923
VL - 13
JO - Pharmaceutics
JF - Pharmaceutics
IS - 9
M1 - 1433
ER -
