Peptide-based fluorescent chemical sensors for the specific detection of Cu2+ and S2−

Chaowei Hao, Xuanming Guo, Qi Lai, Yongxin Li, Baomin Fan, Guangzhi Zeng, Zhenxiu He*, Jiang Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

19 Citations (Scopus)


Cu2+ and S2− play important roles in our environment, so it is beneficial to develop sensors capable of detecting Cu2+ and S2− in biological samples. To accomplish this goal, a new peptide-based fluorescent chemical sensor L (FITC-Ahx-His-Glu-Phe-Cys-NH2) has been designed and synthesized. It can specifically recognize Cu2+ by forming a L-Cu complex which can quench the fluorescence of L. The subsequent addition of S2− can remove Cu2+ from the L-Cu complex, thereby restoring the fluorescence in a process described as an “On-Off-On” cycle. Cu2+ and S2− can be detected by L with extremely high sensitivity and the detection limits is 32 nM and 53 nM respectively. Additionally, the sensor L can detect Cu2+ and S2− at physiological pH conditions. The result of this research is the development of a peptide-based fluorescent chemical sensor L, which can specifically detect Cu2+ and S2− in the environment.

Original languageEnglish
Article number119943
Number of pages8
JournalInorganica Chimica Acta
Publication statusPublished - 1 Dec 2020

Scopus Subject Areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

User-Defined Keywords

  • Copper ion detection
  • Fluorescence
  • Peptide-based
  • Sulfur ion detection


Dive into the research topics of 'Peptide-based fluorescent chemical sensors for the specific detection of Cu2+ and S2−'. Together they form a unique fingerprint.

Cite this