Pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report and review of the literature

Wei Hua Yin, Na Guo, Xiao Ying TIAN, Yang Li, Zhi Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)


We present a case of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK-positive LBCL) with a cervical, mesentery, and pelvis cavity mass. Histologic examination of the cervical mass revealed that the lesion was composed of diffuse large immunoblastic-like or plasmablastic-like tumor cells with a sinusoidal growth pattern. The tumor cells were strongly immunoreactive for ALK; revealed a granular cytoplasmic distribution; and were diffusely positive for CD45, CD4, CD138, epithelial membrane antigen, and multiple myeloma oncogene-1 but negative for CD20 and CD79a. The patient underwent 5 courses of cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposid and obtained a remarkable clinical response with regression of mesentery and pelvis cavity mass. We suggest that this distinct subtype of large B-cell lymphoma should belong to the spectrum of pediatric lymphomas and that radiologic examination should be performed to inspect the progression of disease even if the patients experienced complete remission at initial chemotherapy.

Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalPediatric and Developmental Pathology
Issue number4
Publication statusPublished - 2012

Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

User-Defined Keywords

  • Anaplastic lymphoma kinase
  • Children
  • Large B-cell lymphoma
  • Prognosis


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