Paramagnetic 19F chemical shift probes that respond selectively to calcium or citrate levels and signal ester hydrolysis

Peter Harvey; Kirsten H. Chalmers; Elena De Luca; Anurag Mishra; David Parker

doi:10.1002/chem.201200737

Paramagnetic ¹⁹F chemical shift probes that respond selectively to calcium or citrate levels and signal ester hydrolysis

Peter Harvey, Kirsten H. Chalmers, Elena De Luca, Anurag Mishra^*, David Parker^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

51 Citations (Scopus)

Abstract

Paramagnetic magnetic resonance chemical shift probes containing a proximal CF ₃ group have been characterised. Different systems have been created that report reversible changes in calcium ion concentrations in the millimolar regime, signal the presence of citrate selectively in competitive aqueous media and allow the monitoring of remote ester/amide hydrolysis in relayed, irreversible transformations. Chemical shift non-equivalence is amplified by the presence of the proximate lanthanide ion, with a mean separation between the CF ₃ group and the metal ion of 6.4 Å found for a thulium complex, in an X-ray structure of the metal complex aqua adduct. The enhanced rate of longitudinal relaxation of the ¹⁹F nucleus allows faster data acquisition.

Original language	English
Pages (from-to)	8748-8757
Number of pages	10
Journal	Chemistry - A European Journal
Volume	18
Issue number	28
Early online date	11 Jun 2012
DOIs	https://doi.org/10.1002/chem.201200737
Publication status	Published - 9 Jul 2012

User-Defined Keywords

calcium
fluorine
lanthanides
magnetic resonance
paramagnetism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/chem.201200737

Cite this

@article{19039c78bb4b4b8e9187da94acd70d5c,

title = "Paramagnetic 19F chemical shift probes that respond selectively to calcium or citrate levels and signal ester hydrolysis",

abstract = "Paramagnetic magnetic resonance chemical shift probes containing a proximal CF 3 group have been characterised. Different systems have been created that report reversible changes in calcium ion concentrations in the millimolar regime, signal the presence of citrate selectively in competitive aqueous media and allow the monitoring of remote ester/amide hydrolysis in relayed, irreversible transformations. Chemical shift non-equivalence is amplified by the presence of the proximate lanthanide ion, with a mean separation between the CF 3 group and the metal ion of 6.4 {\AA} found for a thulium complex, in an X-ray structure of the metal complex aqua adduct. The enhanced rate of longitudinal relaxation of the 19F nucleus allows faster data acquisition.",

keywords = "calcium, fluorine, lanthanides, magnetic resonance, paramagnetism",

author = "Peter Harvey and Chalmers, {Kirsten H.} and {De Luca}, Elena and Anurag Mishra and David Parker",

note = "EPSRC CRC-UK ERC. Grant Number: FCC 266804 Publisher Copyright: {\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2012",

month = jul,

day = "9",

doi = "10.1002/chem.201200737",

language = "English",

volume = "18",

pages = "8748--8757",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "John Wiley & Sons Ltd",

number = "28",

}

TY - JOUR

T1 - Paramagnetic 19F chemical shift probes that respond selectively to calcium or citrate levels and signal ester hydrolysis

AU - Harvey, Peter

AU - Chalmers, Kirsten H.

AU - De Luca, Elena

AU - Mishra, Anurag

AU - Parker, David

PY - 2012/7/9

Y1 - 2012/7/9

N2 - Paramagnetic magnetic resonance chemical shift probes containing a proximal CF 3 group have been characterised. Different systems have been created that report reversible changes in calcium ion concentrations in the millimolar regime, signal the presence of citrate selectively in competitive aqueous media and allow the monitoring of remote ester/amide hydrolysis in relayed, irreversible transformations. Chemical shift non-equivalence is amplified by the presence of the proximate lanthanide ion, with a mean separation between the CF 3 group and the metal ion of 6.4 Å found for a thulium complex, in an X-ray structure of the metal complex aqua adduct. The enhanced rate of longitudinal relaxation of the 19F nucleus allows faster data acquisition.

AB - Paramagnetic magnetic resonance chemical shift probes containing a proximal CF 3 group have been characterised. Different systems have been created that report reversible changes in calcium ion concentrations in the millimolar regime, signal the presence of citrate selectively in competitive aqueous media and allow the monitoring of remote ester/amide hydrolysis in relayed, irreversible transformations. Chemical shift non-equivalence is amplified by the presence of the proximate lanthanide ion, with a mean separation between the CF 3 group and the metal ion of 6.4 Å found for a thulium complex, in an X-ray structure of the metal complex aqua adduct. The enhanced rate of longitudinal relaxation of the 19F nucleus allows faster data acquisition.

KW - calcium

KW - fluorine

KW - lanthanides

KW - magnetic resonance

KW - paramagnetism

UR - http://www.scopus.com/inward/record.url?scp=84863454568&partnerID=8YFLogxK

UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201200737

U2 - 10.1002/chem.201200737

DO - 10.1002/chem.201200737

M3 - Journal article

AN - SCOPUS:84863454568

SN - 0947-6539

VL - 18

SP - 8748

EP - 8757

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 28

ER -