Panax notoginseng Enhances Wound Healing Efficiency and Quality on Diabetic Rats

Natelie Cho, Cheuk Yan Lee, Kwan Ming Lee, Wai Yin Li, Hiu Yee Kwan, Kevin Kin Man Yue*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetic patients are known to have impaired wound healing and a higher risk of diabetic foot ulcer, which may result in amputation. However, drug dressing for promoting wound healing is rarely found. Most commercial dressings can only address the basic needs for diabetes and usually requires a much longer healing time than for non-diabetes. Sanqi, Notoginseng Radix et Rhizoma, is traditional Chinese medicine that shown the effect on treating hemorrhage can be a solution for diabetic wound.

In the in vivo experiment, the alginate dressing with Sanqi can heal the wound 1.5 times faster than the one without it. In this study, the effect of Sanqi on diabetic wound healing in animal model was investigated. In the animal model, SD rats (male: 200g, 2-3 months old) were induced diabetes by intraperitoneal injection, Streptozotocin (STZ) (50mg/kg/day) or sham control (0.1M sodium citrate, pH 4.5), for 2 continuous days. By excising the dorsal skin portion (2cmx2cm), full thickness wounds were created in rats. In each rat, the wound was treated with (a) alginate dressing, and (b) Sanqi alginate dressing. Digital images of the wound site were made twice a week for 3 weeks. The wounds were found 9% faster in terms of wound area percentage decrease than general alginate dressing.

Our results, therefore, suggested Sanqi might contribute in promoting diabetic wound healing efficiency suggesting a new dressing solution to better address chronic wound in a cost-effective manner.

Aims/hypothesis: Sanqi, Latin Pharmaceutical Name is Notoginseng Radix et Rhizoma, a traditional Chinese medicine that shown the effect on treating hemorrhage, may play a role in efficient wound healing in diabetic subjects. We tested whether Sanqi contribute to the healing effect of diabetic wound healing.

Methods: In this study, the effects of Sanqi on wound healing in both diabetic and non-diabetic animals were investigated. In the animal model, SD rats (male: 200g, 2-3 months old) were induced diabetes by intraperitoneal injection, Streptozotocin (STZ) (50mg/kg/day) or sham control (0.1M sodium citrate, pH 4.5) for 2 continuous days. By excising the dorsal skin portion (2cmx2cm), full thickness wounds were created in rats. In each rat, the wound was treated with (a) alginate dressing, and (b) Sanqi alginate dressing. Following the treatment, digital images of the wound site were made twice a week for 3 weeks. HPLC was conducted to indicate the majority active components present in Sanqi, which may participate in the wound-healing event. And the antimicrobial ability of Sanqi in alginate dressing was evaluated. 

Results: In both diabetic and non-diabetic animals, higher wound healing rate was found under the treatment of Panax notoginseng when comparing with both positive and negative controls.

Conclusion/interpretation: Our results, therefore, suggested Panax notoginseng might contribute in promoting diabetic wound healing efficiency.
Original languageEnglish
Article numberS1003
Number of pages5
JournalHSOA Journal of Alternative, Complementary & Integrative Medicine
Volume5
Issue number5
DOIs
Publication statusPublished - 16 Apr 2019

User-Defined Keywords

  • Diabetes
  • Herbal therapy
  • Notoginseng Radix et Rhizoma
  • Sanqi
  • Wound Healing

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