A chiral palladium/copper (Pd/Cu) co-catalytic system which could enable asymmetric ring opening reaction of azabenzonorbornadienes with terminal alkynes is reported. This system comprises palladium(II) acetate [Pd(OAc)2]/(R)-xyl-Binap and copper(I) triflate (CuOTf). A good substrate scope was found, with excellent enantioselective outcomes (up to >99.9 % ee). A reaction mechanism involving two metal complexes is also proposed.
|Number of pages||6|
|Journal||Advanced Synthesis & Catalysis|
|Publication status||Published - 11 Oct 2013|