Palladium/Copper Complexes Co-Catalyzed Highly Enantioselective Ring Opening Reaction of Azabenzonorbornadienes with Terminal Alkynes

Baomin Fan, Sifeng Li, Hualei Chen, Zhiwu Lu, Shanshan Liu, Qingjing Yang, Lu Yu, Jianbin Xu, Yongyun Zhou, Jun Wang

Research output: Contribution to journalArticlepeer-review

Abstract

A chiral palladium/copper (Pd/Cu) co-catalytic system which could enable asymmetric ring opening reaction of azabenzonorbornadienes with terminal alkynes is reported. This system comprises palladium(II) acetate [Pd(OAc)2]/(R)-xyl-Binap and copper(I) triflate (CuOTf). A good substrate scope was found, with excellent enantioselective outcomes (up to >99.9 % ee). A reaction mechanism involving two metal complexes is also proposed.
Original languageEnglish
Pages (from-to)2827-2832
Number of pages6
JournalAdvanced Synthesis & Catalysis
Volume355
Issue number14-15
DOIs
Publication statusPublished - 11 Oct 2013

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