Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

Dong Sheng Lee; Pui Ying Choy; Chau Ming So; Jun Wang; Chak Po Lau; Fuk Yee Kwong

doi:10.1039/c2ra21667a

Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

Dong Sheng Lee, Pui Ying Choy, Chau Ming So, Jun Wang, Chak Po Lau, Fuk Yee Kwong^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

38 Citations (Scopus)

Abstract

This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.

Original language	English
Pages (from-to)	9179-9182
Number of pages	4
Journal	RSC Advances
Volume	2
Issue number	24
Early online date	2 Aug 2012
DOIs	https://doi.org/10.1039/c2ra21667a
Publication status	Published - 14 Oct 2012

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title = "Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates",

abstract = "This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.",

author = "Lee, {Dong Sheng} and Choy, {Pui Ying} and So, {Chau Ming} and Jun Wang and Lau, {Chak Po} and Kwong, {Fuk Yee}",

note = "We thank the Research Grants Council of Hong Kong (CERG: PolyU5012/09P) and State Key Laboratory of Chirosciences (4-BBX3) for financial support.",

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T1 - Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

AU - Lee, Dong Sheng

AU - Choy, Pui Ying

AU - So, Chau Ming

AU - Wang, Jun

AU - Lau, Chak Po

AU - Kwong, Fuk Yee

N1 - We thank the Research Grants Council of Hong Kong (CERG: PolyU5012/09P) and State Key Laboratory of Chirosciences (4-BBX3) for financial support.

PY - 2012/10/14

Y1 - 2012/10/14

N2 - This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.

AB - This study reports the first general Pd-catalyzed direct arylation of polyfluoroarenes with aryl tosylates/mesylates. A wide range of polyfluoroarenes can be coupled with both aryl tosylates and mesylates under relatively mild reaction conditions (90 °C, in the presence of a weak base KOAc, without any additional acid additives). Moreover, a one-pot sequential C-H bond functionalization/C-N bond coupling has been successfully accomplished by employing one single Pd/CM-phos catalyst system.

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Palladium-catalyzed direct arylation of polyfluoroarenes with aryl tosylates and mesylates

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