Palladium-Catalyzed Asymmetric Ring Opening Reaction of Azabenzonorbornadienes with Aromatic Amines

Zhiwu Lu, Jun Wang*, Baiqiu Han, Sifeng Li, Yongyun Zhou, Baomin Fan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A palladium/(R)-Binap catalyst for asymmetric ring opening reaction of azabenzonorbornadienes with amines was developed that afforded the corresponding substituted dihydronaphthalenes in good yields (up to 97%) with excellent enantioselectivities (up to >99% ee). To the best of our knowledge, this represents the first palladium-catalyzed asymmetric ring opening reaction of azabenzonorbornadienes with heteronucleophiles.

Original languageEnglish
Pages (from-to)3121-3125
JournalAdvanced Synthesis & Catalysis
Volume357
Issue number14-15
DOIs
Publication statusPublished - 2015

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