Palladium-catalyzed asymmetric hydrophosphorylation of alkynes: facile access to P-stereogenic phosphinates

Zhiping Yang, Xiaodong Gu, Li-Biao Han, Jun (Joelle) Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the importance of P-chiral organophosphorus compounds in asymmetric catalysis, transition metal-catalyzed methods for accessing P-chiral phosphine derivatives are still limited. Herein, a catalytic enantioselective method for the synthesis of P-stereogenic alkenylphosphinates is developed through asymmetric hydrophosphorylation of alkynes. This process is demonstrated for a wide range of racemic phosphinates and leads to diverse P-stereogenic alkenylphosphinates directly.
Original languageEnglish
Pages (from-to)7451-7455
Number of pages5
JournalChemical Science
Volume11
Issue number28
DOIs
Publication statusPublished - 28 Jul 2020

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