Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway

Qiang Zhang; Yonghui Yuan; Jianchun Cui; Tingting Xiao; Daqing Jiang

doi:10.1016/j.biopha.2016.01.019

Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway

Qiang Zhang, Yonghui Yuan, Jianchun Cui, Tingting Xiao, Daqing Jiang^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

60 Citations (Scopus)

Abstract

Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-reversed PF-inhibited proliferation and invasion, and knockdown of Notch-enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer.

Original language	English
Pages (from-to)	197-203
Number of pages	7
Journal	Biomedicine and Pharmacotherapy
Volume	78
DOIs	https://doi.org/10.1016/j.biopha.2016.01.019
Publication status	Published - Mar 2016

User-Defined Keywords

Breast cancer
Invasion
Notch-1
Paeoniflorin
Proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biopha.2016.01.019

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title = "Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway",

abstract = "Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-reversed PF-inhibited proliferation and invasion, and knockdown of Notch-enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer.",

keywords = "Breast cancer, Invasion, Notch-1, Paeoniflorin, Proliferation",

author = "Qiang Zhang and Yonghui Yuan and Jianchun Cui and Tingting Xiao and Daqing Jiang",

note = "This research were funded by Wu Jieping Medical Foundation (grant number: 320.6750.14070) and Science and Technology Fund of Liaoning Province (grant number: 20141183). Publisher Copyright: {\textcopyright} 2016 Elsevier Masson SAS. All rights reserved.",

year = "2016",

month = mar,

doi = "10.1016/j.biopha.2016.01.019",

language = "English",

volume = "78",

pages = "197--203",

journal = "Biomedicine and Pharmacotherapy",

issn = "0753-3322",

publisher = "Elsevier Masson s.r.l.",

}

TY - JOUR

T1 - Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway

AU - Zhang, Qiang

AU - Yuan, Yonghui

AU - Cui, Jianchun

AU - Xiao, Tingting

AU - Jiang, Daqing

N1 - This research were funded by Wu Jieping Medical Foundation (grant number: 320.6750.14070) and Science and Technology Fund of Liaoning Province (grant number: 20141183). Publisher Copyright: © 2016 Elsevier Masson SAS. All rights reserved.

PY - 2016/3

Y1 - 2016/3

N2 - Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-reversed PF-inhibited proliferation and invasion, and knockdown of Notch-enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer.

AB - Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess anti-tumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-reversed PF-inhibited proliferation and invasion, and knockdown of Notch-enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer.

KW - Breast cancer

KW - Invasion

KW - Notch-1

KW - Paeoniflorin

KW - Proliferation

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U2 - 10.1016/j.biopha.2016.01.019

DO - 10.1016/j.biopha.2016.01.019

M3 - Journal article

C2 - 26898442

AN - SCOPUS:84958682675

SN - 0753-3322

VL - 78

SP - 197

EP - 203

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

ER -

Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-signaling pathway

Abstract

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