Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame

Agriculture & Biology

• aspartame 93%
• nitric oxide synthase 70%
• oxidants 62%
• hepatocytes 57%
• rats 33%
• animals 24%
• liver 20%
• caspase-8 17%
• methotrexate 15%
• heat-shock protein 70 13%
• nitric oxide 10%
• methanol 9%
• protein synthesis 8%
• artificial sweeteners 8%
• tumor necrosis factors 7%
• DNA fragmentation 6%
• metabolism 6%
• mitogen-activated protein kinase 6%
• albino 5%
• thiols 5%
• glutathione peroxidase 5%
• apoptosis 5%
• phosphotransferases (kinases) 4%
• glutathione 4%
• lipid peroxidation 4%
• catalase 4%
• superoxide dismutase 4%
• brain 4%
• metabolites 3%
• antioxidants 3%
• body weight 3%
• gene expression 3%
• genes 2%
• proteins 1%

Medicine & Life Sciences

• Aspartame 100%
• Oxidants 66%
• Nitric Oxide Synthase 62%
• Hepatocytes 53%
• Animals 29%
• Liver 18%
• HSP70 Heat-Shock Proteins 14%
• Caspase 8 13%
• Methanol 12%
• Methotrexate 11%
• Mitogen-Activated Protein Kinase 10 10%
• Nitric Oxide 9%
• Sweetening Agents 8%
• Sulfhydryl Compounds 6%
• DNA Fragmentation 6%
• NF-kappa B 6%
• Glutathione Peroxidase 6%
• Catalase 5%
• Lipid Peroxidation 5%
• Protein Kinases 5%
• Superoxide Dismutase 5%
• Glutathione 5%
• Wistar Rats 4%
• Antioxidants 4%
• Proteins 4%
• Body Weight 4%
• Tumor Necrosis Factor-alpha 4%
• Weights and Measures 3%
• Apoptosis 3%
• Gene Expression 3%
• Brain 2%
• Genes 2%