Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni; Wai Lun Man; Shek Man Yiu; Man Ho; Myra Ting Wai Cheung; Chi Chiu Ko; Chi Ming Che; Yun Wah Lam; Tai Chu Lau

doi:10.1039/c2sc01031c

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni, Wai Lun Man, Shek Man Yiu, Man Ho, Myra Ting Wai Cheung, Chi Chiu Ko, Chi Ming Che, Yun Wah Lam^*, Tai Chu Lau^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

46 Citations (Scopus)

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os ^VI(N)Cl ₃(Hazole) ₂] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

Original language	English
Pages (from-to)	1582-1588
Number of pages	7
Journal	Chemical Science
Volume	3
Issue number	5
Early online date	3 Feb 2012
DOIs	https://doi.org/10.1039/c2sc01031c
Publication status	Published - 1 May 2012

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Chemistry(all)

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title = "Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents",

abstract = "Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.",

author = "Ni, {Wen Xiu} and Man, {Wai Lun} and Yiu, {Shek Man} and Man Ho and Cheung, {Myra Ting Wai} and Ko, {Chi Chiu} and Che, {Chi Ming} and Lam, {Yun Wah} and Lau, {Tai Chu}",

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doi = "10.1039/c2sc01031c",

language = "English",

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T1 - Osmium(vi) nitrido complexes bearing azole heterocycles

T2 - A new class of antitumor agents

AU - Ni, Wen Xiu

AU - Man, Wai Lun

AU - Yiu, Shek Man

AU - Ho, Man

AU - Cheung, Myra Ting Wai

AU - Ko, Chi Chiu

AU - Che, Chi Ming

AU - Lam, Yun Wah

AU - Lau, Tai Chu

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

AB - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

UR - http://www.scopus.com/inward/record.url?scp=84859336852&partnerID=8YFLogxK

U2 - 10.1039/c2sc01031c

DO - 10.1039/c2sc01031c

M3 - Journal article

AN - SCOPUS:84859336852

SN - 2041-6520

VL - 3

SP - 1582

EP - 1588

JO - Chemical Science

JF - Chemical Science

IS - 5

ER -

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Abstract

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