Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni, Wai Lun Man, Shek Man Yiu, Man Ho, Myra Ting Wai Cheung, Chi Chiu Ko, Chi Ming Che, Yun Wah Lam*, Tai Chu Lau*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

Original languageEnglish
Pages (from-to)1582-1588
Number of pages7
JournalChemical Science
Volume3
Issue number5
Early online date3 Feb 2012
DOIs
Publication statusPublished - 1 May 2012

Scopus Subject Areas

  • Chemistry(all)

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