Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Meng Ye, Wan-Qiong Huang, Zi-Xin Li, Chuan-Xian Wang, Tao Liu, Yunzhou Chen, Catherine Hong-Huan Hor, Wai-Lun Man*, Wen-Xiu Ni*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.
Original languageEnglish
Pages (from-to)2468-2471
Number of pages4
JournalChemical Communications
Volume58
Issue number15
Early online date4 Jan 2022
DOIs
Publication statusPublished - 21 Feb 2022

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Catalysis

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