Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Meng Ye; Wan-Qiong Huang; Zi-Xin Li; Chuan-Xian Wang; Tao Liu; Yunzhou Chen; Catherine Hong-Huan Hor; Wai-Lun Man; Wen-Xiu Ni

doi:10.1039/d1cc05148b

Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Meng Ye, Wan-Qiong Huang, Zi-Xin Li, Chuan-Xian Wang, Tao Liu, Yunzhou Chen, Catherine Hong-Huan Hor, Wai-Lun Man^*, Wen-Xiu Ni^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

8 Citations (Scopus)

Abstract

We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.

Original language	English
Pages (from-to)	2468-2471
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	15
Early online date	4 Jan 2022
DOIs	https://doi.org/10.1039/d1cc05148b
Publication status	Published - 21 Feb 2022

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

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10.1039/d1cc05148b

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title = "Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis",

abstract = "We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.",

author = "Meng Ye and Wan-Qiong Huang and Zi-Xin Li and Chuan-Xian Wang and Tao Liu and Yunzhou Chen and Hor, {Catherine Hong-Huan} and Wai-Lun Man and Wen-Xiu Ni",

note = "Funding Information: We thank the Guangdong Major Project of Basic and Applied Basic Research (No. 2019B030302009), the Li Ka Shing Foundation Cross-Disciplinary Research Grant (2020LKSFG01F) and Shantou University Medical College. W.-L. M. is grateful for the seed money from the Faculty of Science of Hong Kong Baptist University. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2022",

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day = "21",

doi = "10.1039/d1cc05148b",

language = "English",

volume = "58",

pages = "2468--2471",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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}

TY - JOUR

T1 - Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

AU - Ye, Meng

AU - Huang, Wan-Qiong

AU - Li, Zi-Xin

AU - Wang, Chuan-Xian

AU - Liu, Tao

AU - Chen, Yunzhou

AU - Hor, Catherine Hong-Huan

AU - Man, Wai-Lun

AU - Ni, Wen-Xiu

N1 - Funding Information: We thank the Guangdong Major Project of Basic and Applied Basic Research (No. 2019B030302009), the Li Ka Shing Foundation Cross-Disciplinary Research Grant (2020LKSFG01F) and Shantou University Medical College. W.-L. M. is grateful for the seed money from the Faculty of Science of Hong Kong Baptist University. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2022/2/21

Y1 - 2022/2/21

N2 - We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.

AB - We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.

UR - http://www.scopus.com/inward/record.url?scp=85124805645&partnerID=8YFLogxK

U2 - 10.1039/d1cc05148b

DO - 10.1039/d1cc05148b

M3 - Journal article

SN - 1359-7345

VL - 58

SP - 2468

EP - 2471

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Abstract

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