Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen Xiu Ni; Wai Lun Man; Myra Ting Wai Cheung; Raymond Wai Yin Sun; Yuan Lan Shu; Yun Wah Lam; Chi Ming Che; Tai Chu Lau

doi:10.1039/c0cc04515b

Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen Xiu Ni
, Wai Lun Man
, Myra Ting Wai Cheung
, Raymond Wai Yin Sun
, Yuan Lan Shu
, Yun Wah Lam^*
, Chi Ming Che^*
, Tai Chu Lau^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

48 Citations (Scopus)

Abstract

A nitridoosmium(vi) complex [Os^VI(N)(sap)(OH₂)Cl] (H₂sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

Original language	English
Pages (from-to)	2140-2142
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	7
Early online date	4 Jan 2011
DOIs	https://doi.org/10.1039/c0cc04515b
Publication status	Published - 21 Feb 2011

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10.1039/c0cc04515b

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title = "Osmium(vi) complexes as a new class of potential anti-cancer agents",

abstract = "A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.",

author = "Ni, \{Wen Xiu\} and Man, \{Wai Lun\} and Cheung, \{Myra Ting Wai\} and Sun, \{Raymond Wai Yin\} and Shu, \{Yuan Lan\} and Lam, \{Yun Wah\} and Che, \{Chi Ming\} and Lau, \{Tai Chu\}",

note = "We acknowledge the Research Grants Council of Hong Kong (CityU 101607), the Area of Excellence Scheme (AoE/P-10/01) administered by the University Grants Committee (HKSAR, China), and the ITF-Tier 2 project (ITS/134/09FP) administrated by the Innovation and Technology Commission (HKSAR, China).",

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doi = "10.1039/c0cc04515b",

language = "English",

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pages = "2140--2142",

journal = "Chemical Communications",

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T1 - Osmium(vi) complexes as a new class of potential anti-cancer agents

AU - Ni, Wen Xiu

AU - Man, Wai Lun

AU - Cheung, Myra Ting Wai

AU - Sun, Raymond Wai Yin

AU - Shu, Yuan Lan

AU - Lam, Yun Wah

AU - Che, Chi Ming

AU - Lau, Tai Chu

N1 - We acknowledge the Research Grants Council of Hong Kong (CityU 101607), the Area of Excellence Scheme (AoE/P-10/01) administered by the University Grants Committee (HKSAR, China), and the ITF-Tier 2 project (ITS/134/09FP) administrated by the Innovation and Technology Commission (HKSAR, China).

PY - 2011/2/21

Y1 - 2011/2/21

N2 - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

AB - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

UR - https://www.scopus.com/pages/publications/79551475837

U2 - 10.1039/c0cc04515b

DO - 10.1039/c0cc04515b

M3 - Journal article

C2 - 21203649

AN - SCOPUS:79551475837

SN - 1359-7345

VL - 47

SP - 2140

EP - 2142

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

Osmium(vi) complexes as a new class of potential anti-cancer agents

Abstract

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