Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen Xiu Ni; Wai Lun Man; Myra Ting Wai Cheung; Raymond Wai Yin Sun; Yuan Lan Shu; Yun Wah Lam; Chi Ming Che; Tai Chu Lau

doi:10.1039/c0cc04515b

Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen Xiu Ni, Wai Lun Man, Myra Ting Wai Cheung, Raymond Wai Yin Sun, Yuan Lan Shu, Yun Wah Lam^*, Chi Ming Che^*, Tai Chu Lau^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

45 Citations (Scopus)

Abstract

A nitridoosmium(vi) complex [Os^VI(N)(sap)(OH₂)Cl] (H₂sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

Original language	English
Pages (from-to)	2140-2142
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	7
Early online date	4 Jan 2011
DOIs	https://doi.org/10.1039/c0cc04515b
Publication status	Published - 21 Feb 2011

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c0cc04515b

Cite this

@article{8bc669d1c34e424a94a286608978b1fe,

title = "Osmium(vi) complexes as a new class of potential anti-cancer agents",

abstract = "A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.",

author = "Ni, {Wen Xiu} and Man, {Wai Lun} and Cheung, {Myra Ting Wai} and Sun, {Raymond Wai Yin} and Shu, {Yuan Lan} and Lam, {Yun Wah} and Che, {Chi Ming} and Lau, {Tai Chu}",

year = "2011",

month = feb,

day = "21",

doi = "10.1039/c0cc04515b",

language = "English",

volume = "47",

pages = "2140--2142",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Osmium(vi) complexes as a new class of potential anti-cancer agents

AU - Ni, Wen Xiu

AU - Man, Wai Lun

AU - Cheung, Myra Ting Wai

AU - Sun, Raymond Wai Yin

AU - Shu, Yuan Lan

AU - Lam, Yun Wah

AU - Che, Chi Ming

AU - Lau, Tai Chu

PY - 2011/2/21

Y1 - 2011/2/21

N2 - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

AB - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

UR - http://www.scopus.com/inward/record.url?scp=79551475837&partnerID=8YFLogxK

U2 - 10.1039/c0cc04515b

DO - 10.1039/c0cc04515b

M3 - Journal article

C2 - 21203649

AN - SCOPUS:79551475837

SN - 1359-7345

VL - 47

SP - 2140

EP - 2142

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

Osmium(vi) complexes as a new class of potential anti-cancer agents

Abstract

Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this