Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

Pengfei Li; Sau Hing Chan; Albert S.C. Chan; Fuk Yee Kwong

doi:10.1039/c1ob06191g

Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

Pengfei Li
, Sau Hing Chan
, Albert S.C. Chan^*
, Fuk Yee Kwong

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

51 Citations (Scopus)

Abstract

A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94% yields with 68-96% ee.

Original language	English
Pages (from-to)	7997-7999
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	23
Early online date	16 Sept 2011
DOIs	https://doi.org/10.1039/c1ob06191g
Publication status	Published - 7 Dec 2011

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@article{f26e49298728468382530deba52296b8,

title = "Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone",

abstract = "A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94\% yields with 68-96\% ee.",

author = "Pengfei Li and Chan, \{Sau Hing\} and Chan, \{Albert S.C.\} and Kwong, \{Fuk Yee\}",

note = "We gratefully thank the European Commission FP7-201431 (CATAFLU.OR) and PolyU Internal Grant DA (A-PD0X) for financial support. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2011",

year = "2011",

month = dec,

day = "7",

doi = "10.1039/c1ob06191g",

language = "English",

volume = "9",

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journal = "Organic and Biomolecular Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

AU - Li, Pengfei

AU - Chan, Sau Hing

AU - Chan, Albert S.C.

AU - Kwong, Fuk Yee

PY - 2011/12/7

Y1 - 2011/12/7

N2 - A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94% yields with 68-96% ee.

AB - A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94% yields with 68-96% ee.

UR - https://www.scopus.com/pages/publications/81255128908

U2 - 10.1039/c1ob06191g

DO - 10.1039/c1ob06191g

M3 - Journal article

C2 - 21969174

AN - SCOPUS:81255128908

SN - 1477-0520

VL - 9

SP - 7997

EP - 7999

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 23

ER -

Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

Abstract

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