Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

Pengfei Li, Sau Hing Chan, Albert S.C. Chan*, Fuk Yee Kwong

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

49 Citations (Scopus)

Abstract

A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94% yields with 68-96% ee.

Original languageEnglish
Pages (from-to)7997-7999
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number23
Early online date16 Sept 2011
DOIs
Publication statusPublished - 7 Dec 2011

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