Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone

Pengfei Li; Fang Fang; Ji Chen; Jun Wang

doi:10.1016/j.tetasy.2013.11.012

Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone

Pengfei Li^*
, Fang Fang
, Ji Chen
, Jun Wang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

38 Citations (Scopus)

Abstract

An efficient enantioselective aza-Michael addition of pyrazole to chalcone was established. In the presence of the primary amine derived from cinchona alkaloid and acidic additive, the reactions afforded 1,4-adducts in high yields (up to 98%) with 68–88% ee.

Original language	English
Pages (from-to)	98-101
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.tetasy.2013.11.012
Publication status	Published - 15 Jan 2014

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10.1016/j.tetasy.2013.11.012

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title = "Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone",

abstract = "An efficient enantioselective aza-Michael addition of pyrazole to chalcone was established. In the presence of the primary amine derived from cinchona alkaloid and acidic additive, the reactions afforded 1,4-adducts in high yields (up to 98\%) with 68–88\% ee. ",

author = "Pengfei Li and Fang Fang and Ji Chen and Jun Wang",

year = "2014",

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doi = "10.1016/j.tetasy.2013.11.012",

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T1 - Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone

AU - Li, Pengfei

AU - Fang, Fang

AU - Chen, Ji

AU - Wang, Jun

PY - 2014/1/15

Y1 - 2014/1/15

N2 - An efficient enantioselective aza-Michael addition of pyrazole to chalcone was established. In the presence of the primary amine derived from cinchona alkaloid and acidic additive, the reactions afforded 1,4-adducts in high yields (up to 98%) with 68–88% ee.

AB - An efficient enantioselective aza-Michael addition of pyrazole to chalcone was established. In the presence of the primary amine derived from cinchona alkaloid and acidic additive, the reactions afforded 1,4-adducts in high yields (up to 98%) with 68–88% ee.

U2 - 10.1016/j.tetasy.2013.11.012

DO - 10.1016/j.tetasy.2013.11.012

M3 - Journal article

SN - 0957-4166

VL - 25

SP - 98

EP - 101

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 1

ER -

Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone

Abstract

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