Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone

Pengfei Li*, Fang Fang, Ji Chen, Jun Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient enantioselective aza-Michael addition of pyrazole to chalcone was established. In the presence of the primary amine derived from cinchona alkaloid and acidic additive, the reactions afforded 1,4-adducts in high yields (up to 98%) with 68–88% ee.

Original languageEnglish
Pages (from-to)98-101
JournalTetrahedron Asymmetry
Volume25
Issue number1
DOIs
Publication statusPublished - 2014

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