TY - JOUR
T1 - Organic Nanoparticles Based on D-A-D Small Molecule
T2 - Self-Assembly, Photophysical Properties, and Synergistic Photodynamic/Photothermal Effects
AU - Yue, Liangliang
AU - Li, Haolan
AU - Sun, Qi
AU - Luo, Xiaogang
AU - Wu, Fengshou
AU - Zhu, Xunjin
N1 - Funding Information:
Xunjin Zhu acknowledges the financial support from the Innovation and Technology Commission (UIM/373).
This work was supported by the National Natural Science Foundation of China (NSFC) (grant no. 21601142), the Key Project of Scientific Research Project of Hubei Provincial Department of Education (grant no. D20201504), and the Outstanding Young and Middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province: “Biomass chemical technologies and materials” (Grant No. T201908).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/1/2
Y1 - 2022/1/2
N2 - Cancer is one of the major diseases threatening human health. Traditional cancer treatments have notable side-effects as they can damage the immune system. Recently, phototherapy, as a potential strategy for clinical cancer therapy, has received wide attention due to its minimal invasiveness and high efficiency. Herein, a small organic molecule (PTA) with a D-A-D structure was prepared via a Sonogashira coupling reaction between the electron-withdrawing dibromo-perylenediimide and electron-donating 4-ethynyl-N,N-diphenylaniline. The amphiphilic organic molecule was then transformed into nanoparticles (PTA-NPs) through the self-assembling method. Upon laser irradiation at 635 nm, PTA-NPs displayed a high photothermal conversion efficiency (PCE = 43%) together with efficient reactive oxygen species (ROS) generation. The fluorescence images also indicated the production of ROS in cancer cells with PTA-NPs. In addition, the biocompatibility and photocytotoxicity of PTA-NPs were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead cell co-staining test. Therefore, the as-prepared organic nanomaterials were demonstrated as promising nanomaterials for cancer phototherapy in the clinic.
AB - Cancer is one of the major diseases threatening human health. Traditional cancer treatments have notable side-effects as they can damage the immune system. Recently, phototherapy, as a potential strategy for clinical cancer therapy, has received wide attention due to its minimal invasiveness and high efficiency. Herein, a small organic molecule (PTA) with a D-A-D structure was prepared via a Sonogashira coupling reaction between the electron-withdrawing dibromo-perylenediimide and electron-donating 4-ethynyl-N,N-diphenylaniline. The amphiphilic organic molecule was then transformed into nanoparticles (PTA-NPs) through the self-assembling method. Upon laser irradiation at 635 nm, PTA-NPs displayed a high photothermal conversion efficiency (PCE = 43%) together with efficient reactive oxygen species (ROS) generation. The fluorescence images also indicated the production of ROS in cancer cells with PTA-NPs. In addition, the biocompatibility and photocytotoxicity of PTA-NPs were evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead cell co-staining test. Therefore, the as-prepared organic nanomaterials were demonstrated as promising nanomaterials for cancer phototherapy in the clinic.
KW - Organic nanomaterials
KW - Perylene diimide
KW - Photothermal therapy
KW - Reactive oxygen species
KW - Self-assembly
UR - http://www.scopus.com/inward/record.url?scp=85122735130&partnerID=8YFLogxK
U2 - 10.3390/ma15020502
DO - 10.3390/ma15020502
M3 - Journal article
AN - SCOPUS:85122735130
SN - 1996-1944
VL - 15
JO - Materials
JF - Materials
IS - 2
M1 - 502
ER -
