Organic Molecules for Optical Imaging

Michael Hon Wah Lam*, Ga Lai Law, Chi Sing LEE, Ka-Leung WONG

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

3 Citations (Scopus)

Abstract

This chapter introduces a series of specially designed organic-based dyes and probes that are useful in bioimaging and in vitro/in vivo chemosensing to reveal the locales and conditions of specific subcellular structures, the activity of selected cytochemical processes, and the in vitro syntheses, trafficking, interactions, and degradations of specific biomolecules. It looks at the basic building blocks of advanced molecular imaging and sensing tools: the numerous chromophores and fluorophores that have been developed over the last few centuries. The chapter presents a brief introduction to the fundamental principles of various fluorescent techniques that are commonly applied in bioimaging and in vitro and in vivo bio- and chemosensing. It then discusses two/multi-photon induced emission and time-resolved imaging. Bioluminescence imaging has become a powerful methodology for molecular imaging of small laboratory animals, which allows the study of ongoing biological processes in vivo. In biomedical applications, photoacoustic imaging offers a number of advantages.

Original languageEnglish
Title of host publicationThe Chemistry of Molecular Imaging
PublisherWiley-Blackwell
Pages245-274
Number of pages30
Volume9781118093276
ISBN (Electronic)9781118854754
ISBN (Print)9781118093276
DOIs
Publication statusPublished - 22 Dec 2014

Scopus Subject Areas

  • Chemistry(all)
  • Engineering(all)
  • Medicine(all)

User-Defined Keywords

  • Bioluminescence imaging
  • Molecular probes
  • Optical imaging
  • Organic molecules
  • Organic-based chromophores
  • Organic-based fluorophores
  • Photoacoustic imaging
  • Time-resolved imaging
  • Two/multi-photon induced emission

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