TY - JOUR
T1 - Optimization of fabrication conditions of high-efficiency ultrafiltration membranes using methods of uniform design and regression analysis
AU - Leung, Suei Yee Lam
AU - Chan, Wing Hong
AU - Luk, Chi Hang
N1 - Funding Information:
Financial support (HKBU 2003/97P) from the Research Grant Council of the UGC is gratefully acknowledged. Special thanks are given to K.T. Fang and K.W. Ng for their valuable advice and help.
PY - 2000/11/13
Y1 - 2000/11/13
N2 - In this work, an experimental design with 18 represented treatment-points was used to study the influences of one qualitative and three quantitative variables of the fabrication conditions of membranes on the membrane performances. The uniform design (UD) method was used to select 18 represented treatment points from the experimental domain studied. The pure flux and the retention abilities of each of the four protein references, namely the egg white lysozyme (15 kDa), egg white albumin (45 kDa), bovine serum albumin (67 kDa) and bovine γ-globulin (150 kDa), of duplicate membranes prepared at each of the selected 18 experimental points were determined. The data collected from each of the selected 18 experimental points were then regressed with the studied casting conditions by using the SAS software. An acceptable regression equation was obtained in most cases studied. Several high-efficiency ultrafiltration membranes for separating the 150- and 67-kDa molecules, 67- and 45-kDa molecules and 45- and 15-kDa molecules were successfully prepared by following the predictions given by using the statistical analyses. Copyright (C) 2000 Elsevier Science B.V.
AB - In this work, an experimental design with 18 represented treatment-points was used to study the influences of one qualitative and three quantitative variables of the fabrication conditions of membranes on the membrane performances. The uniform design (UD) method was used to select 18 represented treatment points from the experimental domain studied. The pure flux and the retention abilities of each of the four protein references, namely the egg white lysozyme (15 kDa), egg white albumin (45 kDa), bovine serum albumin (67 kDa) and bovine γ-globulin (150 kDa), of duplicate membranes prepared at each of the selected 18 experimental points were determined. The data collected from each of the selected 18 experimental points were then regressed with the studied casting conditions by using the SAS software. An acceptable regression equation was obtained in most cases studied. Several high-efficiency ultrafiltration membranes for separating the 150- and 67-kDa molecules, 67- and 45-kDa molecules and 45- and 15-kDa molecules were successfully prepared by following the predictions given by using the statistical analyses. Copyright (C) 2000 Elsevier Science B.V.
KW - High-efficiency UF membrane
KW - Polyamidesulfonamide
KW - Regression analysis
KW - Sharpening separation ability
KW - Uniform design method
UR - http://www.scopus.com/inward/record.url?scp=0034645484&partnerID=8YFLogxK
U2 - 10.1016/S0169-7439(00)00098-8
DO - 10.1016/S0169-7439(00)00098-8
M3 - Journal article
AN - SCOPUS:0034645484
SN - 0169-7439
VL - 53
SP - 21
EP - 35
JO - Chemometrics and Intelligent Laboratory Systems
JF - Chemometrics and Intelligent Laboratory Systems
IS - 1-2
ER -