TY - JOUR
T1 - One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication
AU - Brezhnev, Alexander
AU - Tang, Fung Kit
AU - Kwan, Chak Shing
AU - Basabrain, Mohammed S.
AU - Tsoi, James Kit Hon
AU - Matinlinna, Jukka P.
AU - Neelakantan, Prasanna
AU - Leung, Ken Cham Fai
N1 - Funding Information:
K.C.F.L. acknowledges the funding from Hong Kong Baptist University (RC-KRPS-20-21/02, SKLP_2223_P02) and Guangdong Province Zhu Jiang Talents Plan (Project code: 2016ZT06C090) and Guangzhou City Talents Plan (Project code: CYLJTD-201609).
Publisher copyright:
© 2023 The Authors. Published by American Chemical Society
PY - 2023/3/20
Y1 - 2023/3/20
N2 - Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials.
AB - Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials.
KW - antimicrobial
KW - biofilm eradication
KW - cetylpyridinium chloride
KW - drug delivery
KW - mesoporous silica nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85149465769&partnerID=8YFLogxK
U2 - 10.1021/acsabm.2c01080
DO - 10.1021/acsabm.2c01080
M3 - Journal article
C2 - 36862938
SN - 2576-6422
VL - 6
SP - 1221
EP - 1230
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 3
ER -
