One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication

Alexander Brezhnev, Fung Kit Tang, Chak Shing Kwan, Mohammed S. Basabrain, James Kit Hon Tsoi, Jukka P. Matinlinna, Prasanna Neelakantan*, Ken Cham Fai Leung*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

6 Citations (Scopus)


Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (Streptococcus mutans, Actinomyces naeslundii, and Enterococcus faecalis), which are associated with oral infections, caries, and endodontic pathology. The nanoparticle delivery system used in this study prolonged the release of CPC. The manufactured CPC-MSN effectively killed the tested bacteria within the biofilm, and their size allowed them to penetrate into dentinal tubules. This CPC-MSN nanoparticle delivery system demonstrates potential for applications in dental materials.
Original languageEnglish
Pages (from-to)1221–1230
Number of pages10
JournalACS Applied Bio Materials
Issue number3
Early online date2 Mar 2023
Publication statusPublished - 20 Mar 2023

Scopus Subject Areas

  • Biochemistry, medical
  • Chemistry(all)
  • Biomedical Engineering
  • Biomaterials

User-Defined Keywords

  • antimicrobial
  • biofilm eradication
  • cetylpyridinium chloride
  • drug delivery
  • mesoporous silica nanoparticles


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