One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine

Qingya Cao; Jinhang Dai; Ziting Du; Gang Chen; Fukun Li; Ting Qi; Ruiqi Wang; Weilu Wang; Jun Zhao; Chenxi Huang

doi:10.1039/d5ob00577a

One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine

Qingya Cao
, Jinhang Dai^*
, Ziting Du
, Gang Chen
, Fukun Li
, Ting Qi
, Ruiqi Wang
, Weilu Wang
, Jun Zhao
, Chenxi Huang

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

One-pot synthesis of N-acetylglycine from N-acetyl glucosamine using a combination of heterogeneous MgO and Ag₂O was demonstrated, achieving an enhanced yield of 29% in water under mild conditions. Compared to traditional methods, environment unfriendly Strecker reactions are avoided. Experimental and DFT results revealed that 2-acetamido acetaldehyde was identified as the main intermediate. This work provides an example for self-nitrogen supplied synthesis of valuable organonitrogen compounds from chitin biomass.

Original language	English
Pages (from-to)	5126-5132
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	23
Issue number	21
Early online date	7 May 2025
DOIs	https://doi.org/10.1039/d5ob00577a
Publication status	Published - 7 Jun 2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

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10.1039/d5ob00577a

Cite this

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title = "One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine",

abstract = "One-pot synthesis of N-acetylglycine from N-acetyl glucosamine using a combination of heterogeneous MgO and Ag2O was demonstrated, achieving an enhanced yield of 29\% in water under mild conditions. Compared to traditional methods, environment unfriendly Strecker reactions are avoided. Experimental and DFT results revealed that 2-acetamido acetaldehyde was identified as the main intermediate. This work provides an example for self-nitrogen supplied synthesis of valuable organonitrogen compounds from chitin biomass.",

author = "Qingya Cao and Jinhang Dai and Ziting Du and Gang Chen and Fukun Li and Ting Qi and Ruiqi Wang and Weilu Wang and Jun Zhao and Chenxi Huang",

note = "The authors gratefully acknowledge the support of the National Natural Science Foundation of China (22408032), the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202200844), Graduate Innovative Research Project from Chongqing Technology and Business University (yjscxx2024-284-29) and the Chongqing College Students{\textquoteright} Innovation and Entrepreneurship Training Program (S202411799022). Publisher Copyright: {\textcopyright} 2025 The Royal Society of Chemistry.",

year = "2025",

month = jun,

day = "7",

doi = "10.1039/d5ob00577a",

language = "English",

volume = "23",

pages = "5126--5132",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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}

TY - JOUR

T1 - One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine

AU - Cao, Qingya

AU - Dai, Jinhang

AU - Du, Ziting

AU - Chen, Gang

AU - Li, Fukun

AU - Qi, Ting

AU - Wang, Ruiqi

AU - Wang, Weilu

AU - Zhao, Jun

AU - Huang, Chenxi

N1 - The authors gratefully acknowledge the support of the National Natural Science Foundation of China (22408032), the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202200844), Graduate Innovative Research Project from Chongqing Technology and Business University (yjscxx2024-284-29) and the Chongqing College Students’ Innovation and Entrepreneurship Training Program (S202411799022). Publisher Copyright: © 2025 The Royal Society of Chemistry.

PY - 2025/6/7

Y1 - 2025/6/7

N2 - One-pot synthesis of N-acetylglycine from N-acetyl glucosamine using a combination of heterogeneous MgO and Ag2O was demonstrated, achieving an enhanced yield of 29% in water under mild conditions. Compared to traditional methods, environment unfriendly Strecker reactions are avoided. Experimental and DFT results revealed that 2-acetamido acetaldehyde was identified as the main intermediate. This work provides an example for self-nitrogen supplied synthesis of valuable organonitrogen compounds from chitin biomass.

AB - One-pot synthesis of N-acetylglycine from N-acetyl glucosamine using a combination of heterogeneous MgO and Ag2O was demonstrated, achieving an enhanced yield of 29% in water under mild conditions. Compared to traditional methods, environment unfriendly Strecker reactions are avoided. Experimental and DFT results revealed that 2-acetamido acetaldehyde was identified as the main intermediate. This work provides an example for self-nitrogen supplied synthesis of valuable organonitrogen compounds from chitin biomass.

UR - https://www.scopus.com/pages/publications/105004798785

U2 - 10.1039/d5ob00577a

DO - 10.1039/d5ob00577a

M3 - Journal article

AN - SCOPUS:105004798785

SN - 1477-0520

VL - 23

SP - 5126

EP - 5132

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 21

ER -

One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine

Abstract

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