One-pot green synthesis of N-acetylglycine from renewable N-acetyl glucosamine

Qingya Cao, Jinhang Dai*, Ziting Du, Gang Chen, Fukun Li, Ting Qi, Ruiqi Wang, Weilu Wang, Jun Zhao, Chenxi Huang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

One-pot synthesis of N-acetylglycine from N-acetyl glucosamine using a combination of heterogeneous MgO and Ag2O was demonstrated, achieving an enhanced yield of 29% in water under mild conditions. Compared to traditional methods, environment unfriendly Strecker reactions are avoided. Experimental and DFT results revealed that 2-acetamido acetaldehyde was identified as the main intermediate. This work provides an example for self-nitrogen supplied synthesis of valuable organonitrogen compounds from chitin biomass.

Original languageEnglish
Pages (from-to)5126-5132
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume23
Issue number21
Early online date7 May 2025
DOIs
Publication statusPublished - 7 Jun 2025

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