TY - JOUR
T1 - Occurrence and Partitioning of Bisphenol Analogues in Adults' Blood from China
AU - Jin, Hangbiao
AU - Zhu, Jing
AU - Chen, Zhongjian
AU - Hong, Yanjun
AU - Cai, Zongwei
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (NSFC, 21645010), Science Technology and Innovation Commission of Shenzhen (SZITC 201706), and Hong Kong Baptist University Faculty Research Grant (FRG1/15-16/026).
Publisher copyright:
© 2017 American Chemical Society
PY - 2018/1/16
Y1 - 2018/1/16
N2 - Widespread human exposure and associated adverse health effects led to regulations on the usage of bisphenol A (BPA). Several bisphenol analogues (BPs) have been introduced as BPA alternatives in various applications. However, these BPs have been shown to exhibit similar or even stronger endocrine-disrupting activities compared with that of BPA. Currently, information on the human exposure to BPA alternatives remains limited. In this study, nine BPs were quantified in 81 pairs of plasma and red blood cell (RBC) samples from Chinese participants. In human plasma, the predominant BPs was BPA, bisphenol S (BPS), and bisphenol AF (BPAF), with the mean concentrations of 0.40, 0.15, and 0.073 ng/mL, respectively. BPA (accounting for 63% of total BPs) and BPS (18%) were the major BPs in the RBC fraction. Mass fractions in plasma (Fp) were found to be highest for BPS (mean, 0.78), followed by BPAF (0.71) and BPA (0.67), indicating strong partitioning to the plasma fraction. However, bisphenol AP was more frequently detected in the RBC fraction. Estimated total daily intake (EDI) of BPA was in the range of 0.0048-0.75 μg/kg bw/day for the participants, and adults aged >50 years had comparatively lower EDI. To our knowledge, this is the first study to assess the occurrence and partitioning of BPA alternatives in paired human plasma and RBCs from the Chinese general population.
AB - Widespread human exposure and associated adverse health effects led to regulations on the usage of bisphenol A (BPA). Several bisphenol analogues (BPs) have been introduced as BPA alternatives in various applications. However, these BPs have been shown to exhibit similar or even stronger endocrine-disrupting activities compared with that of BPA. Currently, information on the human exposure to BPA alternatives remains limited. In this study, nine BPs were quantified in 81 pairs of plasma and red blood cell (RBC) samples from Chinese participants. In human plasma, the predominant BPs was BPA, bisphenol S (BPS), and bisphenol AF (BPAF), with the mean concentrations of 0.40, 0.15, and 0.073 ng/mL, respectively. BPA (accounting for 63% of total BPs) and BPS (18%) were the major BPs in the RBC fraction. Mass fractions in plasma (Fp) were found to be highest for BPS (mean, 0.78), followed by BPAF (0.71) and BPA (0.67), indicating strong partitioning to the plasma fraction. However, bisphenol AP was more frequently detected in the RBC fraction. Estimated total daily intake (EDI) of BPA was in the range of 0.0048-0.75 μg/kg bw/day for the participants, and adults aged >50 years had comparatively lower EDI. To our knowledge, this is the first study to assess the occurrence and partitioning of BPA alternatives in paired human plasma and RBCs from the Chinese general population.
UR - http://www.scopus.com/inward/record.url?scp=85041433873&partnerID=8YFLogxK
U2 - 10.1021/acs.est.7b03958
DO - 10.1021/acs.est.7b03958
M3 - Journal article
C2 - 29243481
AN - SCOPUS:85041433873
SN - 0013-936X
VL - 52
SP - 812
EP - 820
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 2
ER -
