Noxious visceral inputs enhance cutaneous tactile response in rat thalamus

Hong Qi ZHANG; Pei Jing Rong; Shi Ping Zhang; Elie D. Al-Chaer; William D. Willis

doi:10.1016/S0304-3940(02)01243-0

Noxious visceral inputs enhance cutaneous tactile response in rat thalamus

Hong Qi ZHANG^*, Pei Jing Rong, Shi Ping Zhang, Elie D. Al-Chaer, William D. Willis

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

16 Citations (Scopus)

Abstract

The current study investigates whether visceral nociceptive inputs affect tactile processing in the thalamic ventroposterior lateral nucleus in anesthetized rats by means of extracellular single unit recordings. Twenty out of the 44 neurons had their response to tactile stimulation increased by preceding nociceptive colorectal distension (CRD), and this influence appear more potent than the opposite effect, tactile on CRD response. There was a dynamic change of tactile response along with CRD response and the background activities as a function of repeated colorectal stimulation. The abnormal neuronal discharge in response to tactile stimulation in the condition of visceral nociception could contribute to the development of referred pain and allodynia.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Neuroscience Letters
Volume	336
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(02)01243-0
Publication status	Published - 16 Jan 2003

Scopus Subject Areas

General Neuroscience

User-Defined Keywords

Allodynia
Rat
Referred pain
Thalamus
Visceral nociception

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10.1016/S0304-3940(02)01243-0

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title = "Noxious visceral inputs enhance cutaneous tactile response in rat thalamus",

abstract = "The current study investigates whether visceral nociceptive inputs affect tactile processing in the thalamic ventroposterior lateral nucleus in anesthetized rats by means of extracellular single unit recordings. Twenty out of the 44 neurons had their response to tactile stimulation increased by preceding nociceptive colorectal distension (CRD), and this influence appear more potent than the opposite effect, tactile on CRD response. There was a dynamic change of tactile response along with CRD response and the background activities as a function of repeated colorectal stimulation. The abnormal neuronal discharge in response to tactile stimulation in the condition of visceral nociception could contribute to the development of referred pain and allodynia.",

keywords = "Allodynia, Rat, Referred pain, Thalamus, Visceral nociception",

author = "ZHANG, {Hong Qi} and Rong, {Pei Jing} and Zhang, {Shi Ping} and Al-Chaer, {Elie D.} and Willis, {William D.}",

note = "Funding Information: The work was supported by Hong Kong CERG grant HKBU2093/01M and NIH grants NS11255 & NS09743. We thank G. Gonzales and Nickie Chan for their technical assistance.",

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doi = "10.1016/S0304-3940(02)01243-0",

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T1 - Noxious visceral inputs enhance cutaneous tactile response in rat thalamus

AU - ZHANG, Hong Qi

AU - Rong, Pei Jing

AU - Zhang, Shi Ping

AU - Al-Chaer, Elie D.

AU - Willis, William D.

N1 - Funding Information: The work was supported by Hong Kong CERG grant HKBU2093/01M and NIH grants NS11255 & NS09743. We thank G. Gonzales and Nickie Chan for their technical assistance.

PY - 2003/1/16

Y1 - 2003/1/16

N2 - The current study investigates whether visceral nociceptive inputs affect tactile processing in the thalamic ventroposterior lateral nucleus in anesthetized rats by means of extracellular single unit recordings. Twenty out of the 44 neurons had their response to tactile stimulation increased by preceding nociceptive colorectal distension (CRD), and this influence appear more potent than the opposite effect, tactile on CRD response. There was a dynamic change of tactile response along with CRD response and the background activities as a function of repeated colorectal stimulation. The abnormal neuronal discharge in response to tactile stimulation in the condition of visceral nociception could contribute to the development of referred pain and allodynia.

AB - The current study investigates whether visceral nociceptive inputs affect tactile processing in the thalamic ventroposterior lateral nucleus in anesthetized rats by means of extracellular single unit recordings. Twenty out of the 44 neurons had their response to tactile stimulation increased by preceding nociceptive colorectal distension (CRD), and this influence appear more potent than the opposite effect, tactile on CRD response. There was a dynamic change of tactile response along with CRD response and the background activities as a function of repeated colorectal stimulation. The abnormal neuronal discharge in response to tactile stimulation in the condition of visceral nociception could contribute to the development of referred pain and allodynia.

KW - Allodynia

KW - Rat

KW - Referred pain

KW - Thalamus

KW - Visceral nociception

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DO - 10.1016/S0304-3940(02)01243-0

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Noxious visceral inputs enhance cutaneous tactile response in rat thalamus

Abstract

Scopus Subject Areas

User-Defined Keywords

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