Novel ent-kaurane dimers from Isodon rubescens var. rubescens

Quanbin Han, Yang Lu, Lili Zhang, Qitai Zheng, Handong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

37 Citations (Scopus)


Three novel asymmetric ent-kaurane dimers xindongnins M-O (1-3) were isolated from Isodon rubescens var. rubescens. Their structures were elucidated by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was determined by single crystal X-ray diffraction, which also confirmed the unique linkage of a single carbon-carbon bond between the two subunits of this dimer. A biogenetic pathway was proposed for the formation of these dimers.

Original languageEnglish
Pages (from-to)2833-2837
Number of pages5
JournalTetrahedron Letters
Issue number13
Publication statusPublished - 22 Mar 2004

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • ent-Kaurane dimer
  • Isodon rubescens var. rubescens
  • Xindongnins M-O


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