Novel ent-kaurane dimers from Isodon rubescens var. rubescens

Quanbin Han; Yang Lu; Lili Zhang; Qitai Zheng; Handong Sun

doi:10.1016/j.tetlet.2004.02.051

Novel ent-kaurane dimers from Isodon rubescens var. rubescens

Quanbin Han, Yang Lu, Lili Zhang, Qitai Zheng, Handong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

37 Citations (Scopus)

Abstract

Three novel asymmetric ent-kaurane dimers xindongnins M-O (1-3) were isolated from Isodon rubescens var. rubescens. Their structures were elucidated by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was determined by single crystal X-ray diffraction, which also confirmed the unique linkage of a single carbon-carbon bond between the two subunits of this dimer. A biogenetic pathway was proposed for the formation of these dimers.

Original language	English
Pages (from-to)	2833-2837
Number of pages	5
Journal	Tetrahedron Letters
Volume	45
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2004.02.051
Publication status	Published - 22 Mar 2004

Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

User-Defined Keywords

ent-Kaurane dimer
Isodon rubescens var. rubescens
Xindongnins M-O

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10.1016/j.tetlet.2004.02.051

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title = "Novel ent-kaurane dimers from Isodon rubescens var. rubescens",

abstract = "Three novel asymmetric ent-kaurane dimers xindongnins M-O (1-3) were isolated from Isodon rubescens var. rubescens. Their structures were elucidated by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was determined by single crystal X-ray diffraction, which also confirmed the unique linkage of a single carbon-carbon bond between the two subunits of this dimer. A biogenetic pathway was proposed for the formation of these dimers.",

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author = "Quanbin Han and Yang Lu and Lili Zhang and Qitai Zheng and Handong Sun",

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T1 - Novel ent-kaurane dimers from Isodon rubescens var. rubescens

AU - Han, Quanbin

AU - Lu, Yang

AU - Zhang, Lili

AU - Zheng, Qitai

AU - Sun, Handong

PY - 2004/3/22

Y1 - 2004/3/22

N2 - Three novel asymmetric ent-kaurane dimers xindongnins M-O (1-3) were isolated from Isodon rubescens var. rubescens. Their structures were elucidated by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was determined by single crystal X-ray diffraction, which also confirmed the unique linkage of a single carbon-carbon bond between the two subunits of this dimer. A biogenetic pathway was proposed for the formation of these dimers.

AB - Three novel asymmetric ent-kaurane dimers xindongnins M-O (1-3) were isolated from Isodon rubescens var. rubescens. Their structures were elucidated by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was determined by single crystal X-ray diffraction, which also confirmed the unique linkage of a single carbon-carbon bond between the two subunits of this dimer. A biogenetic pathway was proposed for the formation of these dimers.

KW - ent-Kaurane dimer

KW - Isodon rubescens var. rubescens

KW - Xindongnins M-O

UR - http://www.scopus.com/inward/record.url?scp=1542268870&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2004.02.051

DO - 10.1016/j.tetlet.2004.02.051

M3 - Journal article

SN - 0040-4039

VL - 45

SP - 2833

EP - 2837

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 13

ER -

Novel ent-kaurane dimers from Isodon rubescens var. rubescens

Abstract

Scopus Subject Areas

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