Novel ebselen-porphyrin conjugates: Synthesis and nucleic acid interaction study

Zhi Xue; An Xin Hou; Daniel W J KWONG; Rick W K WONG

doi:10.1016/j.bmcl.2007.05.074

Novel ebselen-porphyrin conjugates: Synthesis and nucleic acid interaction study

Zhi Xue, An Xin Hou^*, Daniel W J KWONG, Rick W K WONG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.

Original language	English
Pages (from-to)	4266-4270
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2007.05.074
Publication status	Published - 1 Aug 2007

Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

User-Defined Keywords

Binding mode
Ebselen
HS DNA
Porphyrins

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10.1016/j.bmcl.2007.05.074

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@article{037c6b8e79dc45faa6e5d628e4660e4f,

title = "Novel ebselen-porphyrin conjugates: Synthesis and nucleic acid interaction study",

abstract = "Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.",

keywords = "Binding mode, Ebselen, HS DNA, Porphyrins",

author = "Zhi Xue and Hou, {An Xin} and KWONG, {Daniel W J} and WONG, {Rick W K}",

note = "Funding Information: W.-K.W. thanks the Hong Kong Baptist University (FRG/05-06/II-03) and Hong Kong Research Grants Council (HKBU 2021/03P) for financial support of this work. We thank the reviewers for their critical comments on the manuscript.",

year = "2007",

month = aug,

day = "1",

doi = "10.1016/j.bmcl.2007.05.074",

language = "English",

volume = "17",

pages = "4266--4270",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "15",

}

TY - JOUR

T1 - Novel ebselen-porphyrin conjugates

T2 - Synthesis and nucleic acid interaction study

AU - Xue, Zhi

AU - Hou, An Xin

AU - KWONG, Daniel W J

AU - WONG, Rick W K

N1 - Funding Information: W.-K.W. thanks the Hong Kong Baptist University (FRG/05-06/II-03) and Hong Kong Research Grants Council (HKBU 2021/03P) for financial support of this work. We thank the reviewers for their critical comments on the manuscript.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.

AB - Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.

KW - Binding mode

KW - Ebselen

KW - HS DNA

KW - Porphyrins

UR - http://www.scopus.com/inward/record.url?scp=34347375699&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2007.05.074

DO - 10.1016/j.bmcl.2007.05.074

M3 - Journal article

C2 - 17555963

AN - SCOPUS:34347375699

SN - 0960-894X

VL - 17

SP - 4266

EP - 4270

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Novel ebselen-porphyrin conjugates: Synthesis and nucleic acid interaction study

Abstract

Scopus Subject Areas

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