Novel ebselen-porphyrin conjugates: Synthesis and nucleic acid interaction study

Zhi Xue, An Xin Hou*, Daniel W J KWONG, Rick W K WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Novel porphyrins bearing ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) moiety were synthesized and characterized. Their interactions with herring sperm DNA were studied by means of UV-visible, fluorescence, circular dichroism spectroscopy, and gel electrophoresis.

Original languageEnglish
Pages (from-to)4266-4270
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number15
DOIs
Publication statusPublished - 1 Aug 2007

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • Binding mode
  • Ebselen
  • HS DNA
  • Porphyrins

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