Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers

Li Fan, Jingnan Yang, Ken C F LEUNG, Chaojun Song*, Quan Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Real time monitoring of drug release at specific local sites by a non-invasive imaging method is critical in patient-specific drug administration in order to avoid insufficient or excess drug dosing. In the present work, we designed a specific carrier system for such a purpose using self-decomposable SiO2 nanoparticles (NPs) with the drug being loaded in the center and Au NPs on the SiO2 NPs as the imaging agent. We discovered a correlation between the drug release from the carrier and the morphological evolution of Au NPs, which also left the carrier and changed their aggregation states along with the drug release process. This finding enabled the real time monitoring of the drug release at local sites (e.g. tumor) in a quantitative manner by recording the CT signal evolution of the Au NPs, as demonstrated in vivo using mice bearing Colo-205 xenografts. The present work provided a promising platform for non-invasive real time tracking on the localized drug release, enabling a variety of personalized therapeutic applications.

Original languageEnglish
Pages (from-to)15332-15338
Number of pages7
JournalNanoscale
Volume10
Issue number32
DOIs
Publication statusPublished - 28 Aug 2018

Scopus Subject Areas

  • Materials Science(all)

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