Nickel-catalyzed enantioselective α-heteroarylation of ketones via C–F bond activation to construct all-carbon quaternary stereocenters

Xiaodong Gu, Kexin Liu, Limin Yang, Chengyi Xie, Mingliang Li*, Jun (Joelle) Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

4 Citations (Scopus)

Abstract

Nickel-catalyzed asymmetric α-heteroarylation of ketones with fluorinated heteroarenes is reported via C–F bond activation. A series of ketones and 2-fluoropyridine derivatives with different functional groups proceed well to provide the corresponding products containing all-carbon quaternary stereocenters in good yields (up to 99% yield) and high ee values (up to 99% ee). In addition, drug molecule donepezil could also be compatible under the reaction conditions to afford late-stage diversification of pharmaceuticals.
Original languageEnglish
Pages (from-to)12498-12502
Number of pages5
JournalChemical Science
Volume13
Issue number42
Early online date12 Oct 2022
DOIs
Publication statusPublished - 14 Nov 2022

Scopus Subject Areas

  • Chemistry(all)

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