@article{597359f71bec4967a34130d5180517b6,
title = "Nickel-Catalyzed Direct C (sp3)-H Arylation of Aliphatic Amides with Thiophenes",
abstract = "Nickel-catalyzed heteroarylation of the inactive methyl C(sp3)-H bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes.",
author = "Xie Wang and Longzhi Zhu and Sihai Chen and Xinhua Xu and Au, \{Chak Tong\} and Renhua Qiu",
note = "Funding information: We thank the NSFC (Nos. 21373003, 21273068, J1210040) and the Fundamental Research Funds for the Central Universities for financial support. R.Q. thanks Prof. Nobuaki Kambe (Osaka University, Japan), Prof. Akihiro Orita (Okayama University of Science, Japan), and Prof. Li-Biao Han (AIST, Tsukuba, Japan) for helpful discussions. C.-T.A. thanks HNU for an adjunct professorship. Publisher copyright: {\textcopyright} 2015 American Chemical Society",
year = "2015",
month = nov,
day = "6",
doi = "10.1021/acs.orglett.5b02572",
language = "English",
volume = "17",
pages = "5228--5231",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "21",
}