Ni-catalyzed propargylic substitution reaction: A general and versatile tool to assemble axially chiral phosphorus-containing allenes

A general and versatile Ni-catalyzed propargylic substitution of propargyl acetates has been developed using a broad range of phosphorus nucleophiles, including phosphine oxides, phosphinates, and phosphonates. This methodology offers a practical route to access a series of di-, tri-, and tetra-substituted phosphorus-containing allenes. Mechanistic investigations were conducted to gain insight into the reaction pathway. Our approach provides a powerful tool for the assembly of axially chiral phosphorus-containing allenes.