Abstract
A general and versatile Ni-catalyzed propargylic substitution of propargyl acetates has been developed using a broad range of phosphorus nucleophiles, including phosphine oxides, phosphinates, and phosphonates. This methodology offers a practical route to access a series of di-, tri-, and tetra-substituted phosphorus-containing allenes. Mechanistic investigations were conducted to gain insight into the reaction pathway. Our approach provides a powerful tool for the assembly of axially chiral phosphorus-containing allenes.
Original language | English |
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Article number | 100903 |
Journal | Chem Catalysis |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - 21 Mar 2024 |
Scopus Subject Areas
- Chemistry (miscellaneous)
- Physical and Theoretical Chemistry
- Organic Chemistry
User-Defined Keywords
- allene
- axially chirality
- nickel
- phosphorus
- propargylic substitution
- SDG9: Industry, innovation, and infrastructure