Ni-catalyzed propargylic substitution reaction: A general and versatile tool to assemble axially chiral phosphorus-containing allenes

Xiao-dong Gu, Ka Yan Ngai, Wei Wang, Bin Li, Jun (Joelle) Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

7 Citations (Scopus)

Abstract

A general and versatile Ni-catalyzed propargylic substitution of propargyl acetates has been developed using a broad range of phosphorus nucleophiles, including phosphine oxides, phosphinates, and phosphonates. This methodology offers a practical route to access a series of di-, tri-, and tetra-substituted phosphorus-containing allenes. Mechanistic investigations were conducted to gain insight into the reaction pathway. Our approach provides a powerful tool for the assembly of axially chiral phosphorus-containing allenes.

Original languageEnglish
Article number100903
JournalChem Catalysis
Volume4
Issue number3
DOIs
Publication statusPublished - 21 Mar 2024

Scopus Subject Areas

  • Chemistry (miscellaneous)
  • Physical and Theoretical Chemistry
  • Organic Chemistry

User-Defined Keywords

  • allene
  • axially chirality
  • nickel
  • phosphorus
  • propargylic substitution
  • SDG9: Industry, innovation, and infrastructure

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