New triterpenoid saponins from the roots of Platycodon grandiflorum

Zhendan He, Chunfeng Qiao, Quanbin Han, Ying Wang, Wencai Ye, Hongxi Xu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

50 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the antiviral active fraction of the roots of Platycodon grandiflorum leads to the isolation of three new triterpenoid saponins, platycosides G1–G3 (1–3), as well as two known saponins, platycodin D3 (4), and platycoside E (5). The structures of the new compounds were elucidated on the basis of their spectral data and chemical evidences. The isolated saponins were tested for their antiviral activities against respiratory syncytial virus (RSV), herpes simplex type 1 virus (HSV-1) and influenza type A virus (Flu A). Compound 4 showed weak anti-RSV activity.

Bioassay-directed fractionation of the antiviral active fraction of the roots of Platycodon grandiflorum leads to the isolation of three new triterpenoid saponins, platycosides G1–G3 (1–3), as well as two known saponins, platycodin D3 (4), and platycoside E (5). The structures of the new compounds were elucidated on the basis of their spectral data and chemical evidences. The isolated saponins were tested for their antiviral activities.
Original languageEnglish
Pages (from-to)2211-2215
Number of pages5
JournalTetrahedron
Volume61
Issue number8
DOIs
Publication statusPublished - 21 Feb 2005

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Antiviral activity
  • Campanulaceae
  • Platycodon grandiflorum
  • Platycosides G1-G3
  • Triterpenoid saponin

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