New sesquiterpenes from Litsea verticillata

Hongjie ZHANG, Ghee Teng Tan, Bernard D. Santarsiero, Andrew D. Mesecar, Nguyen Van Hung, Nguyen Manh Cuong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1α,6α-diol (2), 5-epi- eudesm-4(15)-ene-1β,6β-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1β,6β-diol (3), eudesm-4(15)-ene-1β,6α-diol (5), octahydro-4-hydroxy-3α-methyl-7-methylene-α-(1-methylethyl)- 1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-α-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC50 values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) μg/mL (μM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalJournal of Natural Products
Volume66
Issue number5
DOIs
Publication statusPublished - 1 May 2003

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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