TY - JOUR
T1 - New sesquiterpenes from Litsea verticillata
AU - Zhang, Hongjie
AU - Tan, Ghee Teng
AU - Santarsiero, Bernard D.
AU - Mesecar, Andrew D.
AU - Van Hung, Nguyen
AU - Cuong, Nguyen Manh
AU - Soejarto, D. Doel
AU - Pezzuto, John M.
AU - Fong, Harry H.S.
N1 - All work involving plant sample collection, taxonomic identification, bioassay-guided chemical isolation, and structure elucidation in connection with this paper were carried out under a grant administered by the Fogarty International Center, NIH (Grant 1 UO1-TW0101501), as part of an International Cooperative Biodiversity Group (ICBG) program.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1α,6α-diol (2), 5-epi- eudesm-4(15)-ene-1β,6β-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1β,6β-diol (3), eudesm-4(15)-ene-1β,6α-diol (5), octahydro-4-hydroxy-3α-methyl-7-methylene-α-(1-methylethyl)- 1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-α-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC50 values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) μg/mL (μM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis.
AB - Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1α,6α-diol (2), 5-epi- eudesm-4(15)-ene-1β,6β-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1β,6β-diol (3), eudesm-4(15)-ene-1β,6α-diol (5), octahydro-4-hydroxy-3α-methyl-7-methylene-α-(1-methylethyl)- 1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-α-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC50 values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) μg/mL (μM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis.
UR - http://www.scopus.com/inward/record.url?scp=0037850973&partnerID=8YFLogxK
U2 - 10.1021/np020508a
DO - 10.1021/np020508a
M3 - Journal article
C2 - 12762792
AN - SCOPUS:0037850973
SN - 0163-3864
VL - 66
SP - 609
EP - 615
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
